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• W2066293854 abstract "Three fluoroalkylated derivatives (1-3) of the selective estrogen receptor modulator (SERM), raloxifene, have been synthesized. The key step in the synthesis is the C-C bond formation of benzo[b]thiophene and a substituted phenyl group (ring C) using a Stille reaction. The in vitro binding affinities of the substituted raloxifenes 1-3 are 45, 60, 89%, respectively, relative to the affinity of estradiol, which is higher than the affinity of raloxifene itself (25%). When labeled with the positron-emitting radionuclide, these compounds might be useful as PET imaging agents for estrogen receptor-positive breast tumors." @default.
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• W2066293854 date "2003-08-01" @default.
• W2066293854 modified "2023-09-25" @default.
• W2066293854 title "Synthesis and binding affinities of fluoroalkylated raloxifenes" @default.
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• W2066293854 doi "https://doi.org/10.1016/s0968-0896(03)00362-6" @default.
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