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- W2066307788 abstract "Purpose: We determined the acute gastrointestinal (GI), genitourinary (GU), and dermatologic (D) toxicity during dose-escalated three-dimensional conformal radiation therapy (3DCRT). A modified intrarectal balloon (Medrad) was used for prostate gland localization and immobilization.Methods: Forty-six men with clinical category T1c to T3a, and at least one high-risk feature (PSA >10, Gleason ≥7, or MRI evidence of extracapsular extension or seminal vesical invasion) comprised the study cohort. Treatment consisted of hormonal therapy and 4-field 3DCRT using an intrarectal balloon for the initial 15 of 40 treatments. Planning treatment volume dose was 72 Gy (95% normalization). A Mantel–Haenzel Chi-square test compared the distribution of GU, GI, and D symptoms at baseline and at end of treatment (EOT).Results: There was no significant difference between the 2 time points in the proportion of patients with bowel symptoms (p = 0.73), tenesmus (p = 0.27), nocturia (p = 1.00), or GU urgency (p = 0.40). However, there was a significant decrease in GU frequency (70% vs. 50%, p = 0.46) as a result of medical interventions and a significant increase in hemorrhoidal irritation (4% vs. 20%, p = 0.02) and anal cutaneous skin reaction (0% vs. 70%, p < 0.001). By 3 months after EOT compared to baseline, there was no significant difference in the proportion of patients experiencing hemorrhoidal bleeding (4% vs. 8%, p = 0.52), requiring intervention for hemorrhoidal symptoms (7% vs. 5%, p = 0.8), or experiencing persistent anal cutaneous skin reaction (0% vs. 3%, p = 0.31).Conclusion: Dose-escalated 3DCRT using an intrarectal balloon for prostate localization and immobilization was well tolerated. Acute GU, GI, and D symptoms resolved with standard dietary or medical interventions by the EOT or shortly thereafter." @default.
- W2066307788 created "2016-06-24" @default.
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- W2066307788 date "2007-03-01" @default.
- W2066307788 modified "2023-09-26" @default.
- W2066307788 title "397 INTRARECTAL AND ANAL ADMINISTRATION OF LIDOCAINE-PRILOCAINE CREAM IN TRANSRECTAL ULTRASOUND-GUIDED BIOPSY OF THE PROSTATE: A PROSPECTIVE, RANDOMIZED, SINGLE-BLIND, PLACEBO-CONTROLLED TRIAL" @default.
- W2066307788 doi "https://doi.org/10.1016/s1569-9056(07)60395-9" @default.
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