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- W2066321540 abstract "Summary A number of studies suggest that there is a genetic basis for the formation by some haemophilia A patients of antibodies that inactivate factor VIII. In our study, human leucocyte antigen (HLA)-A, B. C, DR and DQ typing was carried out for 44 haemophilia A patients, including 16 who had developed an antibody to factor VIII. In contrast to previous reports, we found no association between HLA-DR antigens and haemophilia A per se or the formation of a factor VIII inhibitor. However, there was an absence of HLA-Cw5 in the 16 haemophilic patients who had formed an antibody to factor VIII. This finding, consistent with a previous report, identified a statistically significant difference in HLA-Cw5 frequency when the inhibitor patient group was compared to multi-transfused haemophilic patients who had no inhibitor (11/28)." @default.
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- W2066321540 date "1990-10-01" @default.
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- W2066321540 title "Histocompatibility antigen patterns in haemophilic patients with factor VIII antibodies" @default.
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- W2066321540 doi "https://doi.org/10.1111/j.1365-2141.1990.tb07878.x" @default.
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