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- W2066334150 endingPage "109" @default.
- W2066334150 startingPage "92" @default.
- W2066334150 abstract "Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC), mainly in the liver. Pemt−/− mice are protected from high-fat diet (HFD)-induced obesity and insulin resistance, but develop severe non-alcoholic fatty liver disease (NAFLD) when fed a HFD, mostly due to impaired VLDL secretion. Oxidative stress is thought to be an essential factor in the progression from simple steatosis to steatohepatitis. Vitamin E is an antioxidant that has been clinically used to improve NAFLD pathology. Our aim was to determine whether supplementation of the diet with vitamin E could attenuate HFD-induced hepatic steatosis and its progression to NASH in Pemt−/− mice. Treatment with vitamin E (0.5 g/kg) for 3 weeks improved VLDL-TG secretion and normalized cholesterol metabolism, but failed to reduce hepatic TG content. Moreover, vitamin E treatment was able to reduce hepatic oxidative stress, inflammation and fibrosis. We also observed abnormal ceramide metabolism in Pemt−/− mice fed a HFD, with elevation of ceramides and other sphingolipids and higher expression of mRNAs for acid ceramidase (Asah1) and ceramide kinase (Cerk). Interestingly, vitamin E supplementation restored Asah1 and Cerk mRNA and sphingolipid levels. Together this study shows that vitamin E treatment efficiently prevented the progression from simple steatosis to steatohepatitis in mice lacking PEMT." @default.
- W2066334150 created "2016-06-24" @default.
- W2066334150 creator A5025551442 @default.
- W2066334150 date "1998-03-01" @default.
- W2066334150 modified "2023-09-26" @default.
- W2066334150 title "Modulation of cell signalling by ceramides" @default.
- W2066334150 cites W112886495 @default.
- W2066334150 cites W126950376 @default.
- W2066334150 cites W1428714033 @default.
- W2066334150 cites W1481994714 @default.
- W2066334150 cites W1488601915 @default.
- W2066334150 cites W1489811008 @default.
- W2066334150 cites W1490342290 @default.
- W2066334150 cites W1501369263 @default.
- W2066334150 cites W1507367690 @default.
- W2066334150 cites W1507410787 @default.
- W2066334150 cites W1508152421 @default.
- W2066334150 cites W1510210099 @default.
- W2066334150 cites W1513288125 @default.
- W2066334150 cites W1516372175 @default.
- W2066334150 cites W1516715449 @default.
- W2066334150 cites W1520176015 @default.
- W2066334150 cites W1520730446 @default.
- W2066334150 cites W1528720934 @default.
- W2066334150 cites W1533740425 @default.
- W2066334150 cites W1535671912 @default.
- W2066334150 cites W1539083823 @default.
- W2066334150 cites W1539477594 @default.
- W2066334150 cites W1542941723 @default.
- W2066334150 cites W1543411735 @default.
- W2066334150 cites W1544997431 @default.
- W2066334150 cites W1562457256 @default.
- W2066334150 cites W1563745823 @default.
- W2066334150 cites W1566441785 @default.
- W2066334150 cites W1567257037 @default.
- W2066334150 cites W1569291911 @default.
- W2066334150 cites W1569837524 @default.
- W2066334150 cites W1576671418 @default.
- W2066334150 cites W1577542502 @default.
- W2066334150 cites W1578317944 @default.
- W2066334150 cites W1581699504 @default.
- W2066334150 cites W1582592433 @default.
- W2066334150 cites W1583264261 @default.
- W2066334150 cites W1585046846 @default.
- W2066334150 cites W1587627449 @default.
- W2066334150 cites W1595133660 @default.
- W2066334150 cites W1601124709 @default.
- W2066334150 cites W1602819342 @default.
- W2066334150 cites W1603514812 @default.
- W2066334150 cites W1607687470 @default.
- W2066334150 cites W1607893122 @default.
- W2066334150 cites W1635474458 @default.
- W2066334150 cites W1663952990 @default.
- W2066334150 cites W1673043020 @default.
- W2066334150 cites W1775924518 @default.
- W2066334150 cites W1776217324 @default.
- W2066334150 cites W1788108435 @default.
- W2066334150 cites W1814884511 @default.
- W2066334150 cites W1843461492 @default.
- W2066334150 cites W1920706136 @default.
- W2066334150 cites W1963719250 @default.
- W2066334150 cites W1963852241 @default.
- W2066334150 cites W1964754625 @default.
- W2066334150 cites W1964781367 @default.
- W2066334150 cites W1967508100 @default.
- W2066334150 cites W1968784427 @default.
- W2066334150 cites W1968956158 @default.
- W2066334150 cites W1969158591 @default.
- W2066334150 cites W1970044546 @default.
- W2066334150 cites W1970347484 @default.
- W2066334150 cites W1970468997 @default.
- W2066334150 cites W1971476654 @default.
- W2066334150 cites W1972189437 @default.
- W2066334150 cites W1975588858 @default.
- W2066334150 cites W1978048485 @default.
- W2066334150 cites W1978071486 @default.
- W2066334150 cites W1979945257 @default.
- W2066334150 cites W1984555985 @default.
- W2066334150 cites W1985233589 @default.
- W2066334150 cites W1988885303 @default.
- W2066334150 cites W1992472345 @default.
- W2066334150 cites W1992615534 @default.
- W2066334150 cites W1992871057 @default.
- W2066334150 cites W1993395343 @default.
- W2066334150 cites W1993876642 @default.
- W2066334150 cites W1996192399 @default.
- W2066334150 cites W1996532068 @default.
- W2066334150 cites W1998166016 @default.
- W2066334150 cites W1999187804 @default.
- W2066334150 cites W1999788591 @default.
- W2066334150 cites W2000823512 @default.
- W2066334150 cites W2003867908 @default.
- W2066334150 cites W200967821 @default.
- W2066334150 cites W2009993180 @default.
- W2066334150 cites W2016470388 @default.
- W2066334150 cites W2016844359 @default.
- W2066334150 cites W2017729786 @default.
- W2066334150 cites W2021230116 @default.