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• W2066342220 endingPage "498" @default.
• W2066342220 startingPage "491" @default.
• W2066342220 abstract "The transcription factor Forkhead-box O (FoxO) is the main transcriptional effector of the Insulin Receptor/Phosphatidylinositol 3-kinase (InR/PI3K) pathway. In a situation of nutrient restriction, the pathway is inactive and FoxO translocates to the nucleus to exert its transcriptional action. In starved females of the cockroach Blattella germanica, the reproductive processes, and in particular the synthesis of juvenile hormone in the corpora allata and that of vitellogenin in the fat body, are arrested. In the present report we examine the possible role of FoxO in the transduction of the nutritional signals to these reproductive events. We first cloned FoxO cDNA from B. germanica (BgFoxO), and showed that its expression is not nutritionally regulated. BgFoxO knockdown using systemic RNAi in vivo in starved females elicited an increase of juvenile hormone biosynthesis, although without modifying mRNA levels of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase-1, HMG-CoA synthase-2, HMG-CoA reductase or methyl farnesoate epoxidase (CYP15A1) in corpora allata. In addition, BgFoxO RNAi treatment produced a remarkable increase of vitellogenin mRNA levels in fat body and of vitellogenin protein in the haemolymph. Our results indicate that BgFoxO plays an inhibitory role on juvenile hormone biosynthesis and vitellogenin production in a situation of nutrient shortage." @default.
• W2066342220 created "2016-06-24" @default.
• W2066342220 creator A5009103547 @default.
• W2066342220 creator A5020238667 @default.
• W2066342220 creator A5025541637 @default.
• W2066342220 date "2012-07-01" @default.
• W2066342220 modified "2023-10-13" @default.
• W2066342220 title "FoxO inhibits juvenile hormone biosynthesis and vitellogenin production in the German cockroach" @default.
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• W2066342220 doi "https://doi.org/10.1016/j.ibmb.2012.03.006" @default.
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