Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066361251> ?p ?o ?g. }
- W2066361251 endingPage "1706" @default.
- W2066361251 startingPage "1696" @default.
- W2066361251 abstract "ABSTRACT For the first time, we report the whole-genome sequence analysis of Chryseobacterium oranimense G311, a multidrug-resistant bacterium, from a cystic fibrosis patient in France, including resistance to colistin. Whole-genome sequencing of C. oranimense G311 was performed using Ion Torrent PGM, and RAST, the EMBL-EBI server, and the Antibiotic Resistance Gene-ANNOTation (ARG-ANNOT) database were used for annotation of all genes, including antibiotic resistance (AR) genes. General features of the C. oranimense G311 draft genome were compared to the other available genomes of Chryseobacterium gleum and Chryseobacterium sp. strain CF314. C. oranimense G311 was found to be resistant to all β-lactams, including imipenem, and to colistin. The genome size of C. oranimense G311 is 4,457,049 bp in length, with 37.70% GC content. We found 27 AR genes in the genome, including β-lactamase genes which showed little similarity to the known β-lactamase genes and could likely be novel. We found the type I polyketide synthase operon followed by a zeaxanthin glycosyltransferase gene in the genome, which could impart the yellow pigmentation of the isolate. We located the O-antigen biosynthesis cluster, and we also discovered a novel capsular polysaccharide biosynthesis cluster. We also found known mutations in the orthologs of the pmrA (E8D), pmrB (L208F and P360Q), and lpxA (G68D) genes. We speculate that the presence of the capsular cluster and mutations in these genes could explain the resistance of this bacterium to colistin. We demonstrate that whole-genome sequencing was successfully applied to decipher the resistome of a multidrug resistance bacterium associated with cystic fibrosis patients." @default.
- W2066361251 created "2016-06-24" @default.
- W2066361251 creator A5012670349 @default.
- W2066361251 creator A5016798150 @default.
- W2066361251 creator A5060454521 @default.
- W2066361251 creator A5082540519 @default.
- W2066361251 date "2015-03-01" @default.
- W2066361251 modified "2023-10-12" @default.
- W2066361251 title "Whole-Genome Sequence of Chryseobacterium oranimense, a Colistin-Resistant Bacterium Isolated from a Cystic Fibrosis Patient in France" @default.
- W2066361251 cites W1522534339 @default.
- W2066361251 cites W1525138800 @default.
- W2066361251 cites W177191043 @default.
- W2066361251 cites W1839006721 @default.
- W2066361251 cites W1882728533 @default.
- W2066361251 cites W1931021041 @default.
- W2066361251 cites W1950540741 @default.
- W2066361251 cites W1966233364 @default.
- W2066361251 cites W1969697265 @default.
- W2066361251 cites W1970743556 @default.
- W2066361251 cites W1979368048 @default.
- W2066361251 cites W1987882175 @default.
- W2066361251 cites W1990377302 @default.
- W2066361251 cites W1993828660 @default.
- W2066361251 cites W1998839424 @default.
- W2066361251 cites W2004548026 @default.
- W2066361251 cites W2009000877 @default.
- W2066361251 cites W2011032506 @default.
- W2066361251 cites W2012019478 @default.
- W2066361251 cites W2012087019 @default.
- W2066361251 cites W2021190135 @default.
- W2066361251 cites W2027400544 @default.
- W2066361251 cites W2029756055 @default.
- W2066361251 cites W2031574400 @default.
- W2066361251 cites W2032024585 @default.
- W2066361251 cites W2037429250 @default.
- W2066361251 cites W2039599894 @default.
- W2066361251 cites W2040581338 @default.
- W2066361251 cites W2045765967 @default.
- W2066361251 cites W2049914201 @default.
- W2066361251 cites W2050788919 @default.
- W2066361251 cites W2064063323 @default.
- W2066361251 cites W2067127365 @default.
- W2066361251 cites W2076663520 @default.
- W2066361251 cites W2088707861 @default.
- W2066361251 cites W2091030812 @default.
- W2066361251 cites W2095871644 @default.
- W2066361251 cites W2096250787 @default.
- W2066361251 cites W2100619015 @default.
- W2066361251 cites W2101444368 @default.
- W2066361251 cites W2104250070 @default.
- W2066361251 cites W2105838577 @default.
- W2066361251 cites W2106355138 @default.
- W2066361251 cites W2107982361 @default.
- W2066361251 cites W2108921340 @default.
- W2066361251 cites W2109066352 @default.
- W2066361251 cites W2114197590 @default.
- W2066361251 cites W2116388403 @default.
- W2066361251 cites W2118688136 @default.
- W2066361251 cites W2120672632 @default.
- W2066361251 cites W2124381039 @default.
- W2066361251 cites W2125825231 @default.
- W2066361251 cites W2125880559 @default.
- W2066361251 cites W2127095060 @default.
- W2066361251 cites W2128908920 @default.
- W2066361251 cites W2130317337 @default.
- W2066361251 cites W2137512613 @default.
- W2066361251 cites W2138738269 @default.
- W2066361251 cites W2140563889 @default.
- W2066361251 cites W2142235297 @default.
- W2066361251 cites W2146805157 @default.
- W2066361251 cites W2152744936 @default.
- W2066361251 cites W2163692090 @default.
- W2066361251 cites W2164190643 @default.
- W2066361251 cites W2165464537 @default.
- W2066361251 cites W2171780940 @default.
- W2066361251 cites W2172112723 @default.
- W2066361251 cites W2259706958 @default.
- W2066361251 cites W4211056710 @default.
- W2066361251 cites W4292806162 @default.
- W2066361251 doi "https://doi.org/10.1128/aac.02417-14" @default.
- W2066361251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4325762" @default.
- W2066361251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25583710" @default.
- W2066361251 hasPublicationYear "2015" @default.
- W2066361251 type Work @default.
- W2066361251 sameAs 2066361251 @default.
- W2066361251 citedByCount "25" @default.
- W2066361251 countsByYear W20663612512016 @default.
- W2066361251 countsByYear W20663612512017 @default.
- W2066361251 countsByYear W20663612512018 @default.
- W2066361251 countsByYear W20663612512019 @default.
- W2066361251 countsByYear W20663612512020 @default.
- W2066361251 countsByYear W20663612512021 @default.
- W2066361251 countsByYear W20663612512022 @default.
- W2066361251 countsByYear W20663612512023 @default.
- W2066361251 crossrefType "journal-article" @default.
- W2066361251 hasAuthorship W2066361251A5012670349 @default.
- W2066361251 hasAuthorship W2066361251A5016798150 @default.
- W2066361251 hasAuthorship W2066361251A5060454521 @default.