Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066371812> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2066371812 endingPage "252" @default.
- W2066371812 startingPage "249" @default.
- W2066371812 abstract "The Trypanosomatidae family, composed of unicellular parasites, causes severe vector-borne diseases that afflict human populations worldwide. Chagas disease, sleeping sickness, as well as different sorts of leishmaniases are amongst the most important infectious diseases produced by Trypanosoma cruzi, Trypanosoma brucei and Leishmania spp., respectively. All these infections are closely related to weak health care services in low-income populations of less developed and least economically developed countries. Search for new therapeutic targets in order to hit these pathogens is of paramount priority, as no effective vaccine is currently in use against any of these parasites. Furthermore, present-day chemotherapy comprises old-fashioned drugs full of important side effects. Besides, they are prone to produce tolerance and resistance as a consequence of their continuous use for decades. DNA topoisomerases (Top) are ubiquitous enzymes responsible for solving the torsional tensions caused during replication and transcription processes, as well as in maintaining genomic stability during DNA recombination. As the inhibition of these enzymes produces cell arrest and triggers cell death, Top inhibitors are among the most effective and most widely used drugs in both cancer and antibacterial therapies. Top relaxation and decatenation activities, which are based on a common nicking–closing cycle involving one or both DNA strands, have been pointed as a promising drug target. Specific inhibitors that bind to the interface of DNA-Top complexes can stabilize Top-mediated transient DNA breaks. In addition, important structural differences have been found between Tops from the Trypanosomatidae family members and Tops from the host. Such dissimilarities make these proteins very interesting for drug design and molecular intervention. The present review is a critical update of the last findings regarding trypanosomatid’s Tops, their new structural features, their involvement both in the physiology and virulence of these parasites, as well as their use as promising targets for drug discovery." @default.
- W2066371812 created "2016-06-24" @default.
- W2066371812 creator A5022590898 @default.
- W2066371812 creator A5045871906 @default.
- W2066371812 date "1997-09-01" @default.
- W2066371812 modified "2023-09-25" @default.
- W2066371812 title "Periodic synthesis of kinetoplast DNA topoisomerase II during the cell cycle" @default.
- W2066371812 cites W1638755431 @default.
- W2066371812 cites W1974589615 @default.
- W2066371812 cites W2035075199 @default.
- W2066371812 cites W2040175583 @default.
- W2066371812 cites W2059944964 @default.
- W2066371812 cites W2074435030 @default.
- W2066371812 cites W2088639926 @default.
- W2066371812 cites W2089218399 @default.
- W2066371812 cites W2099903108 @default.
- W2066371812 cites W2101108802 @default.
- W2066371812 cites W2127671332 @default.
- W2066371812 cites W2139764433 @default.
- W2066371812 cites W2148381730 @default.
- W2066371812 cites W2338852706 @default.
- W2066371812 cites W7685805 @default.
- W2066371812 doi "https://doi.org/10.1016/s0166-6851(97)00076-5" @default.
- W2066371812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9274885" @default.
- W2066371812 hasPublicationYear "1997" @default.
- W2066371812 type Work @default.
- W2066371812 sameAs 2066371812 @default.
- W2066371812 citedByCount "13" @default.
- W2066371812 countsByYear W20663718122014 @default.
- W2066371812 countsByYear W20663718122018 @default.
- W2066371812 crossrefType "journal-article" @default.
- W2066371812 hasAuthorship W2066371812A5022590898 @default.
- W2066371812 hasAuthorship W2066371812A5045871906 @default.
- W2066371812 hasConcept C104317684 @default.
- W2066371812 hasConcept C112418997 @default.
- W2066371812 hasConcept C134935766 @default.
- W2066371812 hasConcept C136764020 @default.
- W2066371812 hasConcept C147897179 @default.
- W2066371812 hasConcept C159047783 @default.
- W2066371812 hasConcept C2776027055 @default.
- W2066371812 hasConcept C2777625466 @default.
- W2066371812 hasConcept C2779502636 @default.
- W2066371812 hasConcept C41008148 @default.
- W2066371812 hasConcept C54355233 @default.
- W2066371812 hasConcept C552990157 @default.
- W2066371812 hasConcept C71928629 @default.
- W2066371812 hasConcept C73573662 @default.
- W2066371812 hasConcept C86803240 @default.
- W2066371812 hasConcept C95444343 @default.
- W2066371812 hasConceptScore W2066371812C104317684 @default.
- W2066371812 hasConceptScore W2066371812C112418997 @default.
- W2066371812 hasConceptScore W2066371812C134935766 @default.
- W2066371812 hasConceptScore W2066371812C136764020 @default.
- W2066371812 hasConceptScore W2066371812C147897179 @default.
- W2066371812 hasConceptScore W2066371812C159047783 @default.
- W2066371812 hasConceptScore W2066371812C2776027055 @default.
- W2066371812 hasConceptScore W2066371812C2777625466 @default.
- W2066371812 hasConceptScore W2066371812C2779502636 @default.
- W2066371812 hasConceptScore W2066371812C41008148 @default.
- W2066371812 hasConceptScore W2066371812C54355233 @default.
- W2066371812 hasConceptScore W2066371812C552990157 @default.
- W2066371812 hasConceptScore W2066371812C71928629 @default.
- W2066371812 hasConceptScore W2066371812C73573662 @default.
- W2066371812 hasConceptScore W2066371812C86803240 @default.
- W2066371812 hasConceptScore W2066371812C95444343 @default.
- W2066371812 hasIssue "1-2" @default.
- W2066371812 hasLocation W20663718121 @default.
- W2066371812 hasLocation W20663718122 @default.
- W2066371812 hasOpenAccess W2066371812 @default.
- W2066371812 hasPrimaryLocation W20663718121 @default.
- W2066371812 hasRelatedWork W2031021272 @default.
- W2066371812 hasRelatedWork W2072778729 @default.
- W2066371812 hasRelatedWork W2124708226 @default.
- W2066371812 hasRelatedWork W2133905263 @default.
- W2066371812 hasRelatedWork W2156119816 @default.
- W2066371812 hasRelatedWork W2527707699 @default.
- W2066371812 hasRelatedWork W2972389032 @default.
- W2066371812 hasRelatedWork W4286203498 @default.
- W2066371812 hasRelatedWork W4310273466 @default.
- W2066371812 hasRelatedWork W4386766948 @default.
- W2066371812 hasVolume "88" @default.
- W2066371812 isParatext "false" @default.
- W2066371812 isRetracted "false" @default.
- W2066371812 magId "2066371812" @default.
- W2066371812 workType "article" @default.