Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066394315> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2066394315 endingPage "342" @default.
- W2066394315 startingPage "339" @default.
- W2066394315 abstract "IgG and IgM class insulin autoantibodies were measured by an enzyme-linked immunosorbent assay in sera from members of the Barts-Windsor-Middlesex prospective family study for Type 1 (insulin-dependent) diabetes. One hundred and twelve individuals from 28 families were selected for study on the basis of a clearly defined islet cell antibody status. IgG insulin autoantibodies were found to be significantly associated with islet cell antibody positive (n=30) versus islet cell antibody negative (n= 57) first degree family relatives (p=0.002), with increased significance (p=0.0003) if complement-fixing (CF)-islet cell antibody individuals (n=20) only were considered. In addition, a significant association of IgG insulin autoantibodies with subsequent development of diabetes was observed within the CF-islet cell antibody positive group (p<0.0003). No such associations were found for IgM insulin autoantibodies, but a higher prevalence of these autoantibodies was observed in islet cell antibody negative first degree relatives (n=57) compared with a control group of 73 Blood Bank donors (p=0.00007), and they were significantly associated with siblings (n=48) rather than parents (n=39), (p=0.001). We conclude that the presence of IgG insulin autoantibodies and CF-islet cell antibodies confer more risk for future development of diabetes than the presence of either marker alone." @default.
- W2066394315 created "2016-06-24" @default.
- W2066394315 creator A5003361227 @default.
- W2066394315 creator A5029677573 @default.
- W2066394315 creator A5038274912 @default.
- W2066394315 creator A5040776990 @default.
- W2066394315 creator A5053853797 @default.
- W2066394315 creator A5071324209 @default.
- W2066394315 creator A5083562757 @default.
- W2066394315 date "1986-05-01" @default.
- W2066394315 modified "2023-10-16" @default.
- W2066394315 title "Insulin autoantibodies in the pre-diabetic period: Correlation with islet cell antibodies and development of diabetes" @default.
- W2066394315 cites W1969699442 @default.
- W2066394315 cites W2019400285 @default.
- W2066394315 cites W2070972996 @default.
- W2066394315 cites W2088173732 @default.
- W2066394315 cites W2108841007 @default.
- W2066394315 cites W2142796657 @default.
- W2066394315 cites W2148672056 @default.
- W2066394315 cites W2412891182 @default.
- W2066394315 doi "https://doi.org/10.1007/bf00452073" @default.
- W2066394315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3522332" @default.
- W2066394315 hasPublicationYear "1986" @default.
- W2066394315 type Work @default.
- W2066394315 sameAs 2066394315 @default.
- W2066394315 citedByCount "120" @default.
- W2066394315 countsByYear W20663943152012 @default.
- W2066394315 countsByYear W20663943152013 @default.
- W2066394315 countsByYear W20663943152014 @default.
- W2066394315 countsByYear W20663943152016 @default.
- W2066394315 countsByYear W20663943152017 @default.
- W2066394315 countsByYear W20663943152022 @default.
- W2066394315 countsByYear W20663943152023 @default.
- W2066394315 crossrefType "journal-article" @default.
- W2066394315 hasAuthorship W2066394315A5003361227 @default.
- W2066394315 hasAuthorship W2066394315A5029677573 @default.
- W2066394315 hasAuthorship W2066394315A5038274912 @default.
- W2066394315 hasAuthorship W2066394315A5040776990 @default.
- W2066394315 hasAuthorship W2066394315A5053853797 @default.
- W2066394315 hasAuthorship W2066394315A5071324209 @default.
- W2066394315 hasAuthorship W2066394315A5083562757 @default.
- W2066394315 hasBestOaLocation W20663943151 @default.
- W2066394315 hasConcept C126322002 @default.
- W2066394315 hasConcept C134018914 @default.
- W2066394315 hasConcept C159654299 @default.
- W2066394315 hasConcept C163764329 @default.
- W2066394315 hasConcept C165220095 @default.
- W2066394315 hasConcept C203014093 @default.
- W2066394315 hasConcept C2779306644 @default.
- W2066394315 hasConcept C2781232474 @default.
- W2066394315 hasConcept C555293320 @default.
- W2066394315 hasConcept C71924100 @default.
- W2066394315 hasConceptScore W2066394315C126322002 @default.
- W2066394315 hasConceptScore W2066394315C134018914 @default.
- W2066394315 hasConceptScore W2066394315C159654299 @default.
- W2066394315 hasConceptScore W2066394315C163764329 @default.
- W2066394315 hasConceptScore W2066394315C165220095 @default.
- W2066394315 hasConceptScore W2066394315C203014093 @default.
- W2066394315 hasConceptScore W2066394315C2779306644 @default.
- W2066394315 hasConceptScore W2066394315C2781232474 @default.
- W2066394315 hasConceptScore W2066394315C555293320 @default.
- W2066394315 hasConceptScore W2066394315C71924100 @default.
- W2066394315 hasIssue "5" @default.
- W2066394315 hasLocation W20663943151 @default.
- W2066394315 hasLocation W20663943152 @default.
- W2066394315 hasOpenAccess W2066394315 @default.
- W2066394315 hasPrimaryLocation W20663943151 @default.
- W2066394315 hasRelatedWork W1973049774 @default.
- W2066394315 hasRelatedWork W1985965417 @default.
- W2066394315 hasRelatedWork W1986775667 @default.
- W2066394315 hasRelatedWork W2030768859 @default.
- W2066394315 hasRelatedWork W2031301348 @default.
- W2066394315 hasRelatedWork W2064538767 @default.
- W2066394315 hasRelatedWork W2069827981 @default.
- W2066394315 hasRelatedWork W2077402733 @default.
- W2066394315 hasRelatedWork W2079112323 @default.
- W2066394315 hasRelatedWork W2109629947 @default.
- W2066394315 hasVolume "29" @default.
- W2066394315 isParatext "false" @default.
- W2066394315 isRetracted "false" @default.
- W2066394315 magId "2066394315" @default.
- W2066394315 workType "article" @default.