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- W2066396782 endingPage "1390" @default.
- W2066396782 startingPage "1377" @default.
- W2066396782 abstract "Background: The objective of this study was to develop a practical green procedure to synthesize quinoxalines and bis-quinoxalines and evaluate their inhibitory effects on the viability of A431 human epidermoid carcinoma cells. Method: A series of quinoxaline and bis-quinoxaline derivatives have been designed and synthesized following a microwave-assisted and bismuth nitrate-catalyzed eco-friendly route. A detailed comparison has been made between microwave-induced protocol with the reactions occurred at room temperature. The structure of the compounds have been elucidated by various spectroscopic methods and finally confirmed by x-ray crystallographic analyses. Results: Two quinoxaline derivatives, compounds 6 and 12 have demonstrated inhibitory effects on the viability of A431 human epidermoid carcinoma cells when compared with HaCaT nontumorigenic human keratinocyte cells. Conclusion: Notably, compound 6 inhibits Stat3 phosphorylation/activation in A431 skin cancer cells." @default.
- W2066396782 created "2016-06-24" @default.
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- W2066396782 date "2013-08-01" @default.
- W2066396782 modified "2023-09-23" @default.
- W2066396782 title "A green approach toward quinoxalines and <i>bis</i>-quinoxalines and their biological evaluation against A431, human skin cancer cell lines" @default.
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- W2066396782 doi "https://doi.org/10.4155/fmc.13.101" @default.
- W2066396782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23919549" @default.
- W2066396782 hasPublicationYear "2013" @default.
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