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• W2066416448 abstract "To investigate the behaviour of silent period (SP) during paired magnetic cortical stimulation.Paired cortical magnetic stimulation is known to inhibit or facilitate motor evoked potentials (MEPs), but no attention has been paid to its effect on SP.SP was measured in the contracted first dorsal interosseus muscle after paired cortical stimuli at given interstimulus intervals (ISIs) in eight healthy subjects. Test stimulus intensity was fixed at 110% of resting threshold (RT), while three levels of conditioning stimulus intensities at 40%, 65% and 90% RT were separately employed. We also examined the effect of progressively increasing the test stimulus intensity (120-150 RT) on SP while maintaining stable conditioning stimulus intensity.65% RT conditioning stimulus shortened the SP at 1-3 ms ISIs with MEP size reduction, and prolonged the SP at 15-20 ms ISIs without affecting MEP size. 90% RT conditioning stimulus showed only SP prolongation, while 40% RT showed only SP shortening at 1 ms ISI. The SP shortening at 2 ms ISI was the most evident with 120% RT test stimulus, but without correlation with the MEP size. The SP prolongation at 15 ms ISI was maximal with 110% RT test stimulus and then almost abolished with 150% RT. The SP shortening at short intervals might be due not only to spinal but also to suprasegmental mechanisms, conceivably mediating cortical excitatory drive to the corticospinal tract. The SP prolongation at intermediate intervals might be due to activation of slowly conducting, intra- or sub-cortical polysynaptic pathways exerting a facilitatory drive on the cortical inhibitory interneurons." @default.
• W2066416448 created "2016-06-24" @default.
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• W2066416448 date "1999-07-01" @default.
• W2066416448 modified "2023-09-27" @default.
• W2066416448 title "Effect of paired transcranial magnetic stimulation on the cortical silent period" @default.
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• W2066416448 doi "https://doi.org/10.1016/s0006-8993(99)01553-x" @default.
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