FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066420512> ?p ?o ?g. }

• W2066420512 endingPage "1000" @default.
• W2066420512 startingPage "993" @default.
• W2066420512 abstract "Corticosteroids (CS) and norepinephrine (NE) support each other's biological effects. Thus, deficiency of cortisol and reduced synovial sympathetic innervation (SSI) may be proinflammatory in rheumatoid arthritis (RA). This study tested the anti-inflammatory cooperativity of CS and NE in human RA synovial tissue. In an in vivo study, 32 patients with RA (with prior CS therapy/without SSI: n=7; without prior CS therapy/with SSI: 6; with prior CS therapy/with SSI: 19) were investigated for synovial inflammation. In an in vitro study with synoviocytes from RA and OA patients, the separate and combined effects of cortisol and NE were studied. In the in vivo study, patients with prior CS therapy/with SSI showed lower secretion of synovial IL-8 than the other groups, lower synovial density of T cells and macrophages, and lower overall inflammation. In the in vitro study, a cooperative suppressive effect of NE (10(-6) M to 10(-8) M) and cortisol (10(-6) M and 10(-7) M) on secretion of IL-8 and TNF from primary early culture mixed RA synoviocytes was observed. This cooperative effect was not observed in OA synoviocytes. In the same RA and OA patients, the cooperative effect was lost in 3rd passage synovial fibroblasts. This study demonstrates the cooperativity of cortisol and NE for inhibition of proinflammatory mediators produced in the synovial tissue of RA patients. These results underscore that coupling of an efficient secretion of systemic cortisol together with local production of NE is important in order to lower synovial inflammation." @default.
• W2066420512 created "2016-06-24" @default.
• W2066420512 creator A5028547482 @default.
• W2066420512 creator A5032141784 @default.
• W2066420512 creator A5039574097 @default.
• W2066420512 creator A5050867453 @default.
• W2066420512 creator A5068594577 @default.
• W2066420512 creator A5085788744 @default.
• W2066420512 date "2002-07-01" @default.
• W2066420512 modified "2023-10-14" @default.
• W2066420512 title "Anti‐inflammatory cooperativity of corticosteroids and norepinephrine in rheumatoid arthritis synovial tissue in vivo and in vitro" @default.
• W2066420512 cites W1534019559 @default.
• W2066420512 cites W1550978342 @default.
• W2066420512 cites W1582177361 @default.
• W2066420512 cites W1967494967 @default.
• W2066420512 cites W1973687723 @default.
• W2066420512 cites W1974555922 @default.
• W2066420512 cites W1994030928 @default.
• W2066420512 cites W1995257163 @default.
• W2066420512 cites W2006724319 @default.
• W2066420512 cites W2041393681 @default.
• W2066420512 cites W2051179264 @default.
• W2066420512 cites W2056763517 @default.
• W2066420512 cites W2077253356 @default.
• W2066420512 cites W2078127406 @default.
• W2066420512 cites W2080931570 @default.
• W2066420512 cites W2106493420 @default.
• W2066420512 cites W2126043069 @default.
• W2066420512 cites W2140318970 @default.
• W2066420512 cites W2152151195 @default.
• W2066420512 cites W2152348310 @default.
• W2066420512 cites W2331287401 @default.
• W2066420512 cites W4232890106 @default.
• W2066420512 cites W4247516111 @default.
• W2066420512 doi "https://doi.org/10.1096/fj.02-0085com" @default.
• W2066420512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12087060" @default.
• W2066420512 hasPublicationYear "2002" @default.
• W2066420512 type Work @default.
• W2066420512 sameAs 2066420512 @default.
• W2066420512 citedByCount "73" @default.
• W2066420512 countsByYear W20664205122012 @default.
• W2066420512 countsByYear W20664205122013 @default.
• W2066420512 countsByYear W20664205122014 @default.
• W2066420512 countsByYear W20664205122015 @default.
• W2066420512 countsByYear W20664205122016 @default.
• W2066420512 countsByYear W20664205122018 @default.
• W2066420512 countsByYear W20664205122019 @default.
• W2066420512 countsByYear W20664205122020 @default.
• W2066420512 countsByYear W20664205122021 @default.
• W2066420512 countsByYear W20664205122022 @default.
• W2066420512 countsByYear W20664205122023 @default.
• W2066420512 crossrefType "journal-article" @default.
• W2066420512 hasAuthorship W2066420512A5028547482 @default.
• W2066420512 hasAuthorship W2066420512A5032141784 @default.
• W2066420512 hasAuthorship W2066420512A5039574097 @default.
• W2066420512 hasAuthorship W2066420512A5050867453 @default.
• W2066420512 hasAuthorship W2066420512A5068594577 @default.
• W2066420512 hasAuthorship W2066420512A5085788744 @default.
• W2066420512 hasConcept C126322002 @default.
• W2066420512 hasConcept C134018914 @default.
• W2066420512 hasConcept C142724271 @default.
• W2066420512 hasConcept C150903083 @default.
• W2066420512 hasConcept C164027704 @default.
• W2066420512 hasConcept C166014724 @default.
• W2066420512 hasConcept C185592680 @default.
• W2066420512 hasConcept C202751555 @default.
• W2066420512 hasConcept C203014093 @default.
• W2066420512 hasConcept C204787440 @default.
• W2066420512 hasConcept C207001950 @default.
• W2066420512 hasConcept C2776164576 @default.
• W2066420512 hasConcept C2776268809 @default.
• W2066420512 hasConcept C2776914184 @default.
• W2066420512 hasConcept C2777077863 @default.
• W2066420512 hasConcept C2777575956 @default.
• W2066420512 hasConcept C2777652487 @default.
• W2066420512 hasConcept C49039625 @default.
• W2066420512 hasConcept C55493867 @default.
• W2066420512 hasConcept C71924100 @default.
• W2066420512 hasConcept C86803240 @default.
• W2066420512 hasConceptScore W2066420512C126322002 @default.
• W2066420512 hasConceptScore W2066420512C134018914 @default.
• W2066420512 hasConceptScore W2066420512C142724271 @default.
• W2066420512 hasConceptScore W2066420512C150903083 @default.
• W2066420512 hasConceptScore W2066420512C164027704 @default.
• W2066420512 hasConceptScore W2066420512C166014724 @default.
• W2066420512 hasConceptScore W2066420512C185592680 @default.
• W2066420512 hasConceptScore W2066420512C202751555 @default.
• W2066420512 hasConceptScore W2066420512C203014093 @default.
• W2066420512 hasConceptScore W2066420512C204787440 @default.
• W2066420512 hasConceptScore W2066420512C207001950 @default.
• W2066420512 hasConceptScore W2066420512C2776164576 @default.
• W2066420512 hasConceptScore W2066420512C2776268809 @default.
• W2066420512 hasConceptScore W2066420512C2776914184 @default.
• W2066420512 hasConceptScore W2066420512C2777077863 @default.
• W2066420512 hasConceptScore W2066420512C2777575956 @default.
• W2066420512 hasConceptScore W2066420512C2777652487 @default.
• W2066420512 hasConceptScore W2066420512C49039625 @default.
• W2066420512 hasConceptScore W2066420512C55493867 @default.

• next