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- W2066430770 abstract "Eleven simple mono-, di- and thihydric phenols were given by stomach tube at a dose of 100 mg/kg body weight. The subsequent 48-hour urines were hydrolyzed, extracted and analyzed by thin-layer and gas chromatography and by infrared spectrophotometry. The mean extent of direct O-methylation was 6.9% with catechol, 6.0% with 4-methylcatechol, 8.9% with 4-ethylcatechol and 6.2% with pyrogallol. The preferred site of methylation was the middle hydroxyl group of pyrogallol and the meta hydroxyl group of 4-methylcatechol. Methoxyl groups were introduced ortho to the hydroxyl group of the monohydric phenols 4-ethyl-phenol, p-cresol and phenol, but this occurred to a very small extent. No O-methylated metabolites were detected following the administration of resorcinol, hydroquinone, hydroxyquinol and phloroglucinol. There was no correlation between the extent of O-methylation of the simple phenols and their potencies as convulsant agents. Formation of anisoles and O-methylation of more than one hydroxyl group were not observed with any of the compounds. The rats dosed with hydroxyquinol but not those given pyrogallol or phloroglucinol excreted small amounts of resorcinol. Metabolites produced by oxidation and unknown metabolites were also observed." @default.
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- W2066430770 date "2009-03-13" @default.
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- W2066430770 title "O-Methylation of Simple Phenols in the Rat" @default.
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- W2066430770 doi "https://doi.org/10.1111/j.1600-0773.1969.tb00526.x" @default.
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