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- W2066442484 abstract "According to a recent suggestion [1] sustaining a dysfunction of insula cortex as a crucial risk factor for the development of anorexia nervosa, in the follow manuscript we propose an hypothesis predicting abnormal somatosensory intra-oral (tongue) patterns in anorexia nervosa (AN). Revealing the logic of the neural mechanisms of gustation is currently one the major topic in neurobiology, given the efforts made so far toward understanding how feeding behaviors become dysfunctional. Food is consumed to maintain energy balance at homeostatic level but also for its rewarding properties independently of the energy status [2]. Exploring how these processes work might significantly contribute to understanding eating disorders. In a seminal study it was reported that the observation of food pictures by underweight subjects with AN led to altered activity in the insula, but also in other regions of midbrain [3]. Given taste perception is peripherally mediated by tongue receptors through a neural system which in humans comprises the anterior insula [4], one could assume that abnormal activity reflecting signals originating from this region, would be mapped in specific somatosensory intra-oral patterns. The insula is part of a neural circuit involved in the extrapolation of food reward properties and controlling the homeostatic appetitive needs [5]. Therefore, we predict that these patterns will be abnormal in AN patients since they would reflects an atypical responsiveness to the rewarding properties of food. This hypothesis could be tested by measuring the modulation of motor evoked potentials recorded from the tongue of this clinical group during the exposure to pictures displaying food with low and/or high nutritional properties. A distorted reactivity to lowand high-rewarding food, as consequence of a functional abnor-" @default.
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- W2066442484 date "2011-10-01" @default.
- W2066442484 modified "2023-09-23" @default.
- W2066442484 title "Somatosensory intra-oral activity reveals functional abnormalities in the insula of anorexia nervosa suffers" @default.
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- W2066442484 doi "https://doi.org/10.1016/j.mehy.2011.07.059" @default.
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