FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066450419> ?p ?o ?g. }

• W2066450419 endingPage "79" @default.
• W2066450419 startingPage "75" @default.
• W2066450419 abstract "Sporadic Alzheimer’s disease (AD) is a genetically complex and chronically progressive neurodegenerative disorder with molecular mechanisms and neuropathologies centering around the amyloidogenic pathway, hyperphosphorylation and aggregation of tau protein, and neurofibrillary degeneration. While cerebrovascular changes have not been traditionally considered to be a central part of AD pathology, a growing body of evidence demonstrates that they may, in fact, be a characteristic feature of the AD brain as well. In particular, microvascular abnormalities within the brain have been associated with pathological AD hallmarks and may precede neurodegeneration. In vivo assessment of microvascular pathology provides a promising approach to develop useful biological markers for early detection and pathological characterization of AD. This review focuses on established blood-based biological marker candidates of microvascular pathology in AD. These candidates include plasma concentration of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) that are increased in AD. Measures of endothelial vasodilatory function including endothelin (ET-1), adrenomedullin (ADM), and atrial natriuretic peptide (ANP), as well as sphingolipids are significantly altered in mild AD or during the predementia stage of mild cognitive impairment (MCI), suggesting sensitivity of these biomarkers for early detection and diagnosis. In conclusion, the emerging clinical diagnostic evidence for the value of blood-based microvascular biomarkers in AD is promising, however, still requires validation in phase II and III diagnostic trials. Moreover, it is still unclear whether the described protein dysbalances are early or downstream pathological events and how the detected systemic microvascular alterations relate to cerebrovascular and neuronal pathologies in the AD brain." @default.
• W2066450419 created "2016-06-24" @default.
• W2066450419 creator A5037109052 @default.
• W2066450419 creator A5042997188 @default.
• W2066450419 creator A5088736025 @default.
• W2066450419 date "2010-01-01" @default.
• W2066450419 modified "2023-10-11" @default.
• W2066450419 title "Blood-based biomarkers of microvascular pathology in Alzheimer’s disease" @default.
• W2066450419 cites W1969809108 @default.
• W2066450419 cites W1976986215 @default.
• W2066450419 cites W1985329800 @default.
• W2066450419 cites W1991278461 @default.
• W2066450419 cites W2005824957 @default.
• W2066450419 cites W2011172106 @default.
• W2066450419 cites W2013615040 @default.
• W2066450419 cites W2021254641 @default.
• W2066450419 cites W2021652661 @default.
• W2066450419 cites W2025774809 @default.
• W2066450419 cites W2028168243 @default.
• W2066450419 cites W2028436804 @default.
• W2066450419 cites W2036974157 @default.
• W2066450419 cites W2039075861 @default.
• W2066450419 cites W2039367496 @default.
• W2066450419 cites W2041851050 @default.
• W2066450419 cites W2042902316 @default.
• W2066450419 cites W2063028981 @default.
• W2066450419 cites W2063223047 @default.
• W2066450419 cites W2078123230 @default.
• W2066450419 cites W2088471254 @default.
• W2066450419 cites W2101397596 @default.
• W2066450419 cites W2102493638 @default.
• W2066450419 cites W2108475007 @default.
• W2066450419 cites W2113708991 @default.
• W2066450419 cites W2127827980 @default.
• W2066450419 cites W2140298351 @default.
• W2066450419 cites W2146788881 @default.
• W2066450419 cites W2156220037 @default.
• W2066450419 cites W2158766477 @default.
• W2066450419 cites W2160808536 @default.
• W2066450419 cites W2397010841 @default.
• W2066450419 cites W4302339855 @default.
• W2066450419 cites W4318600612 @default.
• W2066450419 doi "https://doi.org/10.1016/j.exger.2009.09.005" @default.
• W2066450419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2815204" @default.
• W2066450419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19782124" @default.
• W2066450419 hasPublicationYear "2010" @default.
• W2066450419 type Work @default.
• W2066450419 sameAs 2066450419 @default.
• W2066450419 citedByCount "100" @default.
• W2066450419 countsByYear W20664504192012 @default.
• W2066450419 countsByYear W20664504192013 @default.
• W2066450419 countsByYear W20664504192014 @default.
• W2066450419 countsByYear W20664504192015 @default.
• W2066450419 countsByYear W20664504192016 @default.
• W2066450419 countsByYear W20664504192017 @default.
• W2066450419 countsByYear W20664504192018 @default.
• W2066450419 countsByYear W20664504192019 @default.
• W2066450419 countsByYear W20664504192020 @default.
• W2066450419 countsByYear W20664504192021 @default.
• W2066450419 countsByYear W20664504192022 @default.
• W2066450419 countsByYear W20664504192023 @default.
• W2066450419 crossrefType "journal-article" @default.
• W2066450419 hasAuthorship W2066450419A5037109052 @default.
• W2066450419 hasAuthorship W2066450419A5042997188 @default.
• W2066450419 hasAuthorship W2066450419A5088736025 @default.
• W2066450419 hasBestOaLocation W20664504192 @default.
• W2066450419 hasConcept C142724271 @default.
• W2066450419 hasConcept C169760540 @default.
• W2066450419 hasConcept C207886595 @default.
• W2066450419 hasConcept C2776925932 @default.
• W2066450419 hasConcept C2779134260 @default.
• W2066450419 hasConcept C502032728 @default.
• W2066450419 hasConcept C71924100 @default.
• W2066450419 hasConcept C86803240 @default.
• W2066450419 hasConceptScore W2066450419C142724271 @default.
• W2066450419 hasConceptScore W2066450419C169760540 @default.
• W2066450419 hasConceptScore W2066450419C207886595 @default.
• W2066450419 hasConceptScore W2066450419C2776925932 @default.
• W2066450419 hasConceptScore W2066450419C2779134260 @default.
• W2066450419 hasConceptScore W2066450419C502032728 @default.
• W2066450419 hasConceptScore W2066450419C71924100 @default.
• W2066450419 hasConceptScore W2066450419C86803240 @default.
• W2066450419 hasFunder F4320312041 @default.
• W2066450419 hasFunder F4320318048 @default.
• W2066450419 hasFunder F4320320847 @default.
• W2066450419 hasFunder F4320332161 @default.
• W2066450419 hasIssue "1" @default.
• W2066450419 hasLocation W20664504191 @default.
• W2066450419 hasLocation W20664504192 @default.
• W2066450419 hasLocation W20664504193 @default.
• W2066450419 hasLocation W20664504194 @default.
• W2066450419 hasLocation W20664504195 @default.
• W2066450419 hasLocation W20664504196 @default.
• W2066450419 hasOpenAccess W2066450419 @default.
• W2066450419 hasPrimaryLocation W20664504191 @default.
• W2066450419 hasRelatedWork W1886844647 @default.
• W2066450419 hasRelatedWork W2102136350 @default.
• W2066450419 hasRelatedWork W2112360486 @default.

• next