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- W2066453707 abstract "Proinflammatory and anti-inflammatory events may eventually trigger host response, which acting via a broad spectrum of complex biological processes and molecular interactions may either enhance or resolve the symptoms of acute surgical illness (ASI). Staging the sequence of biological events that take place at the cellular level during the development of ASI may provide leads to effective stage-specific treatments. In line with the hypothesis that proper timing of therapeutic intervention may be crucial to the management of the disease, we have attempted in this review to correlate functional staging to effective treatment of ASI.The present report proposes a conceptual synthesis on the biogenesis and treatment of ASI that is based on known molecular and cellular aspects of human inflammatory sequence and patient data from clinical trials. It also introduces proper timing of therapeutic intervention as a potentially important determinant for the successful outcome of the disease process.Progress in understanding the biogenesis of ASI did not result in successful therapeutic developments as yet. The challenge ahead should be a better understanding of the dynamics of the various processes and regulators in appropriate animal and clinical models of ASI, in order to properly intervene and direct effective therapies for the benefit of critically ill patients." @default.
- W2066453707 created "2016-06-24" @default.
- W2066453707 creator A5000529025 @default.
- W2066453707 creator A5001564648 @default.
- W2066453707 date "2001-09-01" @default.
- W2066453707 modified "2023-09-23" @default.
- W2066453707 title "Correlating functional staging to effective treatment of acute surgical illness" @default.
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- W2066453707 doi "https://doi.org/10.1016/s0002-9610(01)00701-2" @default.
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- W2066453707 hasPublicationYear "2001" @default.
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