FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066454704> ?p ?o ?g. }

• W2066454704 endingPage "2411" @default.
• W2066454704 startingPage "2401" @default.
• W2066454704 abstract "Our previous study demonstrated that anti-double-stranded DNA (anti-dsDNA) antibodies involved in lupus nephritis down-regulate the production of interleukin-2 (IL-2) in T cells, which in turn, contributes to the defective production of cytotoxic cells and to activation-induced cell death in vitro. To reveal novel molecular targets for lupus therapy, the molecular mechanisms of IL-2 down-regulation by anti-dsDNA were studied.Anti-dsDNA monoclonal antibody (mAb) 9D7 was used to study the molecular mechanisms of IL-2 production in vitro. Treatment with arginine-rich peptide, a penetration inhibitor, was used to verify the effect of internalization of anti-dsDNA on the production of IL-2. The signaling pathway for IL-2 expression induced by anti-dsDNA was analyzed by using kinase inhibitors. The therapeutic effects of these inhibitors were evaluated in MRL-lpr/lpr mice.Inhibition of IL-2 production in activated Jurkat cells and human T cells pretreated with mAb 9D7 was reversed by treatment with the arginine-rich peptide. Levels of pAkt and phosphorylated glycogen synthase kinase 3 (pGSK-3) were reduced in activated Jurkat cells that had been pretreated with mAb 9D7. The inhibition of IL-2 production by mAb 9D7 was counteracted by pretreating the cells with LiCl (a GSK-3 inhibitor). However, IL-2 reduction was not recovered in the cells pretreated with ERK and JNK inhibitors. Furthermore, MRL-lpr/lpr mice injected with LiCl or with arginine-rich peptide restored the IL-2 production and reduced the manifestations of lupus.These findings suggest that penetration of T cells by anti-dsDNA may inhibit IL-2 production by activating GSK-3. Moreover, blocking GSK-3 activation as well as inhibiting anti-dsDNA penetration is a potential therapeutic approach for lupus." @default.
• W2066454704 created "2016-06-24" @default.
• W2066454704 creator A5005160185 @default.
• W2066454704 creator A5010530621 @default.
• W2066454704 creator A5011022956 @default.
• W2066454704 creator A5033144499 @default.
• W2066454704 creator A5039195646 @default.
• W2066454704 creator A5042195058 @default.
• W2066454704 creator A5061567323 @default.
• W2066454704 creator A5066698697 @default.
• W2066454704 creator A5088328453 @default.
• W2066454704 date "2010-03-30" @default.
• W2066454704 modified "2023-10-16" @default.
• W2066454704 title "Reversing interleukin-2 inhibition mediated by anti-double-stranded DNA autoantibody ameliorates glomerulonephritis in MRL-lpr/lpr mice" @default.
• W2066454704 cites W1545962866 @default.
• W2066454704 cites W1579988068 @default.
• W2066454704 cites W1587136878 @default.
• W2066454704 cites W1897639093 @default.
• W2066454704 cites W1921702206 @default.
• W2066454704 cites W1975454216 @default.
• W2066454704 cites W1976448458 @default.
• W2066454704 cites W1977631488 @default.
• W2066454704 cites W1979160057 @default.
• W2066454704 cites W1982548356 @default.
• W2066454704 cites W1982595442 @default.
• W2066454704 cites W1984242910 @default.
• W2066454704 cites W1997391571 @default.
• W2066454704 cites W1997881574 @default.
• W2066454704 cites W2000351066 @default.
• W2066454704 cites W2008521296 @default.
• W2066454704 cites W2014085191 @default.
• W2066454704 cites W2019102246 @default.
• W2066454704 cites W2039499913 @default.
• W2066454704 cites W2041036547 @default.
• W2066454704 cites W2052536739 @default.
• W2066454704 cites W2055522356 @default.
• W2066454704 cites W2064650401 @default.
• W2066454704 cites W2065989504 @default.
• W2066454704 cites W2072260477 @default.
• W2066454704 cites W2075450457 @default.
• W2066454704 cites W2078254067 @default.
• W2066454704 cites W2082354842 @default.
• W2066454704 cites W2083874510 @default.
• W2066454704 cites W2138611988 @default.
• W2066454704 cites W2140707292 @default.
• W2066454704 cites W2141299652 @default.
• W2066454704 cites W2143139324 @default.
• W2066454704 cites W2148636382 @default.
• W2066454704 cites W2164146648 @default.
• W2066454704 cites W2166478131 @default.
• W2066454704 cites W2168795791 @default.
• W2066454704 cites W2169398695 @default.
• W2066454704 cites W2170200021 @default.
• W2066454704 cites W4211263332 @default.
• W2066454704 cites W4242768823 @default.
• W2066454704 doi "https://doi.org/10.1002/art.27487" @default.
• W2066454704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20506162" @default.
• W2066454704 hasPublicationYear "2010" @default.
• W2066454704 type Work @default.
• W2066454704 sameAs 2066454704 @default.
• W2066454704 citedByCount "7" @default.
• W2066454704 countsByYear W20664547042013 @default.
• W2066454704 countsByYear W20664547042014 @default.
• W2066454704 countsByYear W20664547042015 @default.
• W2066454704 countsByYear W20664547042016 @default.
• W2066454704 countsByYear W20664547042021 @default.
• W2066454704 crossrefType "journal-article" @default.
• W2066454704 hasAuthorship W2066454704A5005160185 @default.
• W2066454704 hasAuthorship W2066454704A5010530621 @default.
• W2066454704 hasAuthorship W2066454704A5011022956 @default.
• W2066454704 hasAuthorship W2066454704A5033144499 @default.
• W2066454704 hasAuthorship W2066454704A5039195646 @default.
• W2066454704 hasAuthorship W2066454704A5042195058 @default.
• W2066454704 hasAuthorship W2066454704A5061567323 @default.
• W2066454704 hasAuthorship W2066454704A5066698697 @default.
• W2066454704 hasAuthorship W2066454704A5088328453 @default.
• W2066454704 hasConcept C126322002 @default.
• W2066454704 hasConcept C153911025 @default.
• W2066454704 hasConcept C159654299 @default.
• W2066454704 hasConcept C179464577 @default.
• W2066454704 hasConcept C185592680 @default.
• W2066454704 hasConcept C203014093 @default.
• W2066454704 hasConcept C2776090121 @default.
• W2066454704 hasConcept C2776912625 @default.
• W2066454704 hasConcept C2779134260 @default.
• W2066454704 hasConcept C2779912601 @default.
• W2066454704 hasConcept C542903549 @default.
• W2066454704 hasConcept C71924100 @default.
• W2066454704 hasConcept C86803240 @default.
• W2066454704 hasConcept C8891405 @default.
• W2066454704 hasConcept C98274493 @default.
• W2066454704 hasConceptScore W2066454704C126322002 @default.
• W2066454704 hasConceptScore W2066454704C153911025 @default.
• W2066454704 hasConceptScore W2066454704C159654299 @default.
• W2066454704 hasConceptScore W2066454704C179464577 @default.
• W2066454704 hasConceptScore W2066454704C185592680 @default.
• W2066454704 hasConceptScore W2066454704C203014093 @default.
• W2066454704 hasConceptScore W2066454704C2776090121 @default.

• next