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• W2066461878 abstract "The Caenorhabditis elegans vulva has served as a paradigm for how conserved developmental pathways, such as EGF–Ras–MAPK, Notch and Wnt signaling, participate in networks driving animal organogenesis. Here, we discuss an emerging direction in the field, which places vulva research in a quantitative and microevolutionary framework. The final vulval cell fate pattern is known to be robust to change, but only recently has the variation of vulval traits been measured under stochastic, environmental or genetic variation. Whereas the resulting cell fate pattern is invariant among rhabditid nematodes, recent studies indicate that the developmental system has accumulated cryptic variation, even among wild C. elegans isolates. Quantitative differences in the signaling network have emerged through experiments and modeling as the driving force behind cryptic variation in Caenorhabditis species. On a wider evolutionary scale, the establishment of new model species has informed about the presence of qualitative variation in vulval signaling pathways. The Caenorhabditis elegans vulva has served as a paradigm for how conserved developmental pathways, such as EGF–Ras–MAPK, Notch and Wnt signaling, participate in networks driving animal organogenesis. Here, we discuss an emerging direction in the field, which places vulva research in a quantitative and microevolutionary framework. The final vulval cell fate pattern is known to be robust to change, but only recently has the variation of vulval traits been measured under stochastic, environmental or genetic variation. Whereas the resulting cell fate pattern is invariant among rhabditid nematodes, recent studies indicate that the developmental system has accumulated cryptic variation, even among wild C. elegans isolates. Quantitative differences in the signaling network have emerged through experiments and modeling as the driving force behind cryptic variation in Caenorhabditis species. On a wider evolutionary scale, the establishment of new model species has informed about the presence of qualitative variation in vulval signaling pathways." @default.
• W2066461878 created "2016-06-24" @default.
• W2066461878 creator A5036280156 @default.
• W2066461878 creator A5053710443 @default.
• W2066461878 date "2012-04-01" @default.
• W2066461878 modified "2023-09-25" @default.
• W2066461878 title "Robustness and flexibility in nematode vulva development" @default.
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• W2066461878 doi "https://doi.org/10.1016/j.tig.2012.01.002" @default.
• W2066461878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22325232" @default.
• W2066461878 hasPublicationYear "2012" @default.
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