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• W2066462008 abstract "When long polymers such as DNA are in a highly concentrated state they may become entangled, leading to restricted self-diffusion. Here, we investigate the effect of molecular topology on diffusion in concentrated DNA solutions and find surprisingly large effects, even with molecules of modest length and concentration. We measured the diffusion coefficients of linear and relaxed circular molecules by tracking the Brownian motion of single molecules with fluorescence microscopy. Four possible cases were compared: linear molecules surrounded by linear molecules, circular molecules surrounded by linear molecules, linear molecules surrounded by circles, and circles surrounded by circles. In measurements with 45-kbp DNA at 1 mg/ml, we found that circles diffused ≈100 times slower when surrounded by linear molecules than when surrounded by circles. In contrast, linear and circular molecules diffused at nearly the same rate when surrounded by circles, and circles diffused ≈10 times slower than linears when surrounded by linears. Thus, diffusion in entangled DNA solutions strongly depends on topology of both the diffusing molecule and the surrounding molecules. This effect also strongly depends on DNA concentration and length. The differences largely disappeared when the concentration was lowered to 0.1 mg/ml or when the DNA length was lowered to 6 kb. Present theories cannot fully explain these effects." @default.
• W2066462008 created "2016-06-24" @default.
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• W2066462008 creator A5081437873 @default.
• W2066462008 date "2007-03-20" @default.
• W2066462008 modified "2023-10-16" @default.
• W2066462008 title "Strong effects of molecular topology on diffusion of entangled DNA molecules" @default.
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• W2066462008 doi "https://doi.org/10.1073/pnas.0700137104" @default.
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