Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066464582> ?p ?o ?g. }
- W2066464582 endingPage "e1002354" @default.
- W2066464582 startingPage "e1002354" @default.
- W2066464582 abstract "Computational studies as well as in vivo and in vitro results have shown that many cortical neurons fire in a highly irregular manner and at low average firing rates. These patterns seem to persist even when highly rhythmic signals are recorded by local field potential electrodes or other methods that quantify the summed behavior of a local population. Models of the 30-80 Hz gamma rhythm in which network oscillations arise through 'stochastic synchrony' capture the variability observed in the spike output of single cells while preserving network-level organization. We extend upon these results by constructing model networks constrained by experimental measurements and using them to probe the effect of biophysical parameters on network-level activity. We find in simulations that gamma-frequency oscillations are enabled by a high level of incoherent synaptic conductance input, similar to the barrage of noisy synaptic input that cortical neurons have been shown to receive in vivo. This incoherent synaptic input increases the emergent network frequency by shortening the time scale of the membrane in excitatory neurons and by reducing the temporal separation between excitation and inhibition due to decreased spike latency in inhibitory neurons. These mechanisms are demonstrated in simulations and in vitro current-clamp and dynamic-clamp experiments. Simulation results further indicate that the membrane potential noise amplitude has a large impact on network frequency and that the balance between excitatory and inhibitory currents controls network stability and sensitivity to external inputs." @default.
- W2066464582 created "2016-06-24" @default.
- W2066464582 creator A5048701405 @default.
- W2066464582 creator A5078491583 @default.
- W2066464582 date "2012-01-19" @default.
- W2066464582 modified "2023-10-04" @default.
- W2066464582 title "Membrane Properties and the Balance between Excitation and Inhibition Control Gamma-Frequency Oscillations Arising from Feedback Inhibition" @default.
- W2066464582 cites W138041899 @default.
- W2066464582 cites W1484681064 @default.
- W2066464582 cites W1582051163 @default.
- W2066464582 cites W1623755432 @default.
- W2066464582 cites W1653233231 @default.
- W2066464582 cites W1664754259 @default.
- W2066464582 cites W1757730752 @default.
- W2066464582 cites W1804687031 @default.
- W2066464582 cites W1825044724 @default.
- W2066464582 cites W1948806673 @default.
- W2066464582 cites W1967431907 @default.
- W2066464582 cites W1977177901 @default.
- W2066464582 cites W1977450749 @default.
- W2066464582 cites W1977888464 @default.
- W2066464582 cites W1981737644 @default.
- W2066464582 cites W1983967034 @default.
- W2066464582 cites W1985940938 @default.
- W2066464582 cites W1992424371 @default.
- W2066464582 cites W1993569356 @default.
- W2066464582 cites W2001954021 @default.
- W2066464582 cites W2005847560 @default.
- W2066464582 cites W2008284899 @default.
- W2066464582 cites W2008513636 @default.
- W2066464582 cites W2016354087 @default.
- W2066464582 cites W2017957151 @default.
- W2066464582 cites W2024422476 @default.
- W2066464582 cites W2025687881 @default.
- W2066464582 cites W2027205525 @default.
- W2066464582 cites W2030028265 @default.
- W2066464582 cites W2038845124 @default.
- W2066464582 cites W2038916935 @default.
- W2066464582 cites W2039128802 @default.
- W2066464582 cites W2040521907 @default.
- W2066464582 cites W2041359982 @default.
- W2066464582 cites W2043837133 @default.
- W2066464582 cites W2046198005 @default.
- W2066464582 cites W2048922812 @default.
- W2066464582 cites W2057002584 @default.
- W2066464582 cites W2057397555 @default.
- W2066464582 cites W2058184445 @default.
- W2066464582 cites W2067501282 @default.
- W2066464582 cites W2070493184 @default.
- W2066464582 cites W2070914043 @default.
- W2066464582 cites W2072231967 @default.
- W2066464582 cites W2074911271 @default.
- W2066464582 cites W2079600992 @default.
- W2066464582 cites W2079948225 @default.
- W2066464582 cites W2082160346 @default.
- W2066464582 cites W2083547018 @default.
- W2066464582 cites W2093301371 @default.
- W2066464582 cites W2095265457 @default.
- W2066464582 cites W2096006516 @default.
- W2066464582 cites W2101954189 @default.
- W2066464582 cites W2102172922 @default.
- W2066464582 cites W2105966205 @default.
- W2066464582 cites W2106566258 @default.
- W2066464582 cites W2106912553 @default.
- W2066464582 cites W2108776106 @default.
- W2066464582 cites W2112332687 @default.
- W2066464582 cites W2116356678 @default.
- W2066464582 cites W2119443761 @default.
- W2066464582 cites W2120719475 @default.
- W2066464582 cites W2122492788 @default.
- W2066464582 cites W2127610235 @default.
- W2066464582 cites W2128589492 @default.
- W2066464582 cites W2128595101 @default.
- W2066464582 cites W2128949090 @default.
- W2066464582 cites W2129846302 @default.
- W2066464582 cites W2131397159 @default.
- W2066464582 cites W2133125918 @default.
- W2066464582 cites W2135164608 @default.
- W2066464582 cites W2135251966 @default.
- W2066464582 cites W2136592274 @default.
- W2066464582 cites W2138704896 @default.
- W2066464582 cites W2141954297 @default.
- W2066464582 cites W2144215255 @default.
- W2066464582 cites W2146087860 @default.
- W2066464582 cites W2146784106 @default.
- W2066464582 cites W2147576365 @default.
- W2066464582 cites W2149561999 @default.
- W2066464582 cites W2152564840 @default.
- W2066464582 cites W2152896566 @default.
- W2066464582 cites W2153227271 @default.
- W2066464582 cites W2159799383 @default.
- W2066464582 cites W2160645575 @default.
- W2066464582 cites W2170814877 @default.
- W2066464582 cites W2172294131 @default.
- W2066464582 cites W37795517 @default.
- W2066464582 doi "https://doi.org/10.1371/journal.pcbi.1002354" @default.
- W2066464582 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3261914" @default.
- W2066464582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22275859" @default.