FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066475295> ?p ?o ?g. }

• W2066475295 endingPage "43" @default.
• W2066475295 startingPage "33" @default.
• W2066475295 abstract "Most cases of cancer, when detected at an advanced stage, cannot be cured with conventional therapeutic modalities. Therefore, novel targeted approaches such as gene therapy are needed. Nevertheless, while the safety record of gene therapy for cancer has been excellent with more than a thousand patients treated without mortality related to the therapy, clinical efficacy has so far been limited. Moreover, it has become evident that clinical efficacy is partly determined by efficacy of gene delivery. Most adenoviruses used for gene therapy have been based on serotype 5 (Ad5). Unfortunately, recent data suggest that the primary receptor, the coxsackie-adenovirus receptor (CAR) expression in tumors may be highly variable resulting in resistance to adenovirus infection. Consequently, various strategies have been evaluated to modify adenovirus tropism in order to circumvent CAR deficiency, including retargeting complexes or genetic capsid modifications. To further improve tumor penetration and local amplification of the anti-tumor effect, selectively oncolytic agents, e.g. conditionally replicating adenoviruses (CRAds), have been constructed. Infection of tumor cells results in replication, oncolysis, and subsequent release of the virus progeny. Normal tissue is spared due to lack of replication. This review will focus on a discussion of various modifications of adenovirus to achieve efficient anti-tumor effect, and special emphasis will be placed on CRAds in multimodality treatments." @default.
• W2066475295 created "2016-06-24" @default.
• W2066475295 creator A5018878912 @default.
• W2066475295 creator A5062078543 @default.
• W2066475295 date "2005-03-01" @default.
• W2066475295 modified "2023-09-24" @default.
• W2066475295 title "Adenoviruses for treatment of cancer" @default.
• W2066475295 cites W1537740591 @default.
• W2066475295 cites W1963705978 @default.
• W2066475295 cites W1976177182 @default.
• W2066475295 cites W1989790398 @default.
• W2066475295 cites W1991882807 @default.
• W2066475295 cites W1994784565 @default.
• W2066475295 cites W1996591735 @default.
• W2066475295 cites W1998128870 @default.
• W2066475295 cites W2005127084 @default.
• W2066475295 cites W2006361131 @default.
• W2066475295 cites W2016080258 @default.
• W2066475295 cites W2017961829 @default.
• W2066475295 cites W2029080338 @default.
• W2066475295 cites W2029758849 @default.
• W2066475295 cites W2040276875 @default.
• W2066475295 cites W2060753108 @default.
• W2066475295 cites W2063184873 @default.
• W2066475295 cites W2078549990 @default.
• W2066475295 cites W2079018821 @default.
• W2066475295 cites W2084875579 @default.
• W2066475295 cites W2087110939 @default.
• W2066475295 cites W2093424805 @default.
• W2066475295 cites W2098866087 @default.
• W2066475295 cites W2108309692 @default.
• W2066475295 cites W2110592777 @default.
• W2066475295 cites W2115167709 @default.
• W2066475295 cites W2116071714 @default.
• W2066475295 cites W2126305627 @default.
• W2066475295 cites W2137383292 @default.
• W2066475295 cites W2143113338 @default.
• W2066475295 cites W2147961945 @default.
• W2066475295 cites W2156487862 @default.
• W2066475295 cites W2158071204 @default.
• W2066475295 cites W2159913430 @default.
• W2066475295 cites W2168346184 @default.
• W2066475295 cites W2175831465 @default.
• W2066475295 cites W2321756929 @default.
• W2066475295 cites W2325631985 @default.
• W2066475295 doi "https://doi.org/10.1080/07853890410018934" @default.
• W2066475295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15902845" @default.
• W2066475295 hasPublicationYear "2005" @default.
• W2066475295 type Work @default.
• W2066475295 sameAs 2066475295 @default.
• W2066475295 citedByCount "77" @default.
• W2066475295 countsByYear W20664752952012 @default.
• W2066475295 countsByYear W20664752952013 @default.
• W2066475295 countsByYear W20664752952014 @default.
• W2066475295 countsByYear W20664752952015 @default.
• W2066475295 countsByYear W20664752952016 @default.
• W2066475295 countsByYear W20664752952017 @default.
• W2066475295 countsByYear W20664752952019 @default.
• W2066475295 countsByYear W20664752952020 @default.
• W2066475295 countsByYear W20664752952022 @default.
• W2066475295 countsByYear W20664752952023 @default.
• W2066475295 crossrefType "journal-article" @default.
• W2066475295 hasAuthorship W2066475295A5018878912 @default.
• W2066475295 hasAuthorship W2066475295A5062078543 @default.
• W2066475295 hasConcept C104317684 @default.
• W2066475295 hasConcept C111599444 @default.
• W2066475295 hasConcept C121608353 @default.
• W2066475295 hasConcept C126322002 @default.
• W2066475295 hasConcept C135983454 @default.
• W2066475295 hasConcept C159047783 @default.
• W2066475295 hasConcept C202878990 @default.
• W2066475295 hasConcept C203014093 @default.
• W2066475295 hasConcept C2522874641 @default.
• W2066475295 hasConcept C2776954459 @default.
• W2066475295 hasConcept C2777283488 @default.
• W2066475295 hasConcept C2780575108 @default.
• W2066475295 hasConcept C31972630 @default.
• W2066475295 hasConcept C33602714 @default.
• W2066475295 hasConcept C35693153 @default.
• W2066475295 hasConcept C41008148 @default.
• W2066475295 hasConcept C502942594 @default.
• W2066475295 hasConcept C55493867 @default.
• W2066475295 hasConcept C71924100 @default.
• W2066475295 hasConcept C82210918 @default.
• W2066475295 hasConcept C86803240 @default.
• W2066475295 hasConceptScore W2066475295C104317684 @default.
• W2066475295 hasConceptScore W2066475295C111599444 @default.
• W2066475295 hasConceptScore W2066475295C121608353 @default.
• W2066475295 hasConceptScore W2066475295C126322002 @default.
• W2066475295 hasConceptScore W2066475295C135983454 @default.
• W2066475295 hasConceptScore W2066475295C159047783 @default.
• W2066475295 hasConceptScore W2066475295C202878990 @default.
• W2066475295 hasConceptScore W2066475295C203014093 @default.
• W2066475295 hasConceptScore W2066475295C2522874641 @default.
• W2066475295 hasConceptScore W2066475295C2776954459 @default.
• W2066475295 hasConceptScore W2066475295C2777283488 @default.
• W2066475295 hasConceptScore W2066475295C2780575108 @default.
• W2066475295 hasConceptScore W2066475295C31972630 @default.

• next