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• W2066475850 abstract "No AccessJournal of UrologyPediatric Urology1 Sep 2008Transurethral Autologous Myoblast Injection for Treatment of Urinary Incontinence in Children With Classic Bladder Exstrophy Abdol-Mohammad Kajbafzadeh, Azadeh Elmi, Seyedmehdi Payabvash, Amirali Hassanzadeh Salmasi, Parisa Saeedi, Ashraf Mohamadkhani, Zhina Sadeghi, and Laleh Nikfarjam Abdol-Mohammad KajbafzadehAbdol-Mohammad Kajbafzadeh More articles by this author , Azadeh ElmiAzadeh Elmi More articles by this author , Seyedmehdi PayabvashSeyedmehdi Payabvash More articles by this author , Amirali Hassanzadeh SalmasiAmirali Hassanzadeh Salmasi More articles by this author , Parisa SaeediParisa Saeedi More articles by this author , Ashraf MohamadkhaniAshraf Mohamadkhani More articles by this author , Zhina SadeghiZhina Sadeghi More articles by this author , and Laleh NikfarjamLaleh Nikfarjam More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2008.05.057AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The application of autologous myoblasts is an area of active research that may represent an improved alternative for the treatment of urinary incontinence. In this study we investigated the effectiveness of autologous myoblast injection for the treatment of urinary incontinence in children with classic bladder exstrophy. Materials and Methods: Seven boys and 1 girl with persistent urinary incontinence were entered in the study. All children had undergone staged bladder repair and bladder neck reconstruction, and 5 patients had received 1 to 3 transurethral injections of bulking agent. Autologous myoblasts were isolated from abdominal muscle biopsy and cultured before endourethral injection. After the procedure patients underwent pelvic floor electrical stimulation and continued pelvic floor exercises that had been started at least 1 year before injection. The clinical outcomes (based on a 24-hour voiding diary), and cystometric and urodynamic studies were evaluated. Followup ranged from 12 to 18 months (average 15.3). Results: There was a significant, time dependent improvement in urinary continence. At final followup all 7 boys (88% of patients) were socially dry (daytime dryness more than 3 hours), including 3 (38%) who were completely dry. Urodynamic studies revealed an increase in mean bladder capacity (p <0.001), detrusor leak point pressure (p <0.001) and average maximum urinary flow (p <0.01). All 7 boys (vs only 2 patients preoperatively) achieved normal voiding with demonstrable voiding detrusor contraction in the presence of a compliant stable bladder (p <0.05). Conclusions: Our results suggest that transurethral autologous myoblast injection is a valid option for the treatment of structural urinary incontinence in children with classic bladder exstrophy. However, favorable preoperative urodynamic profiles and postoperative pelvic floor electrical stimulation may have contributed to the outcome in this series. References 1 : Long-term results of bladder neck reconstruction for incontinence in children with classical bladder exstrophy or incontinent epispadias. 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Google Scholar Pediatric Urology Research Center, Department of Urology, Children's Hospital Medical Center and Digestive Disease Research Center, Shariati Hospital (AM), Tehran University of Medical Sciences, Tehran, Iran© 2008 by American Urological AssociationFiguresReferencesRelatedDetailsCited byGräs S, Klarskov N and Lose G (2014) Intraurethral Injection of Autologous Minced Skeletal Muscle: A Simple Surgical Treatment for Stress Urinary IncontinenceJournal of Urology, VOL. 192, NO. 3, (850-855), Online publication date: 1-Sep-2014.Peters K, Dmochowski R, Carr L, Robert M, Kaufman M, Sirls L, Herschorn S, Birch C, Kultgen P and Chancellor M (2014) Autologous Muscle Derived Cells for Treatment of Stress Urinary Incontinence in WomenJournal of Urology, VOL. 192, NO. 2, (469-476), Online publication date: 1-Aug-2014.Carr L, Robert M, Kultgen P, Herschorn S, Birch C, Murphy M and Chancellor M (2012) Autologous Muscle Derived Cell Therapy for Stress Urinary Incontinence: A Prospective, Dose Ranging StudyJournal of Urology, VOL. 189, NO. 2, (595-601), Online publication date: 1-Feb-2013.Elmi A, Kajbafzadeh A, Tourchi A, Talab S and Esfahani S (2011) Safety, Efficacy and Health Related Quality of Life of Autologous Myoblast Transplantation for Treatment of Urinary Incontinence in Children With Bladder Exstrophy-Epispadias ComplexJournal of Urology, VOL. 186, NO. 5, (2021-2026), Online publication date: 1-Nov-2011. Volume 180Issue 3September 2008Page: 1098-1105 Advertisement Copyright & Permissions© 2008 by American Urological AssociationKeywordsurethrastem cellsurodynamicsbladder exstrophyurinary incontinenceMetricsAuthor Information Abdol-Mohammad Kajbafzadeh More articles by this author Azadeh Elmi More articles by this author Seyedmehdi Payabvash More articles by this author Amirali Hassanzadeh Salmasi More articles by this author Parisa Saeedi More articles by this author Ashraf Mohamadkhani More articles by this author Zhina Sadeghi More articles by this author Laleh Nikfarjam More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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