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• W2066487764 abstract "Autoimmunity in Type 1 (insulin-dependent) diabetes mellitus was assessed by measuring thyroglobulin antibodies (TGA) using a highly sensitive enzyme immunoassay in 65 young patients with Type 1 diabetes mellitus, 83 healthy first-degree relatives of the patients, 37 healthy control subjects and 67 healthy parents of the control subjects. TGA were found in 78.5% () of patients and were significantly more frequent in patients than in control subjects (40.5%, ; P < 0.01). The prevalence of TGA in patients showed no correlation with age at onset, duration of diabetes or sex. Among the first-degree relatives the prevalence of TGA was significantly increased in mothers of patients than in mothers of the control subjects (80.0% vs. 54.3%, P < 0.05), while not significantly between fathers of patients and fathers of control subjects or between siblings of patients and control subjects. Comparing the TGA levels of TGA-positive subjects, the TGA levels in patients, their parents and their siblings were significantly higher than those in the corresponding control subjects (P < 0.05, P < 0.05 and P < 0.01, respectively). In the present study we thus more clearly demonstrated autoimmune diathesis in patients with Type 1 diabetes and in their first-degree relatives." @default.
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• W2066487764 date "1994-01-01" @default.
• W2066487764 modified "2023-10-18" @default.
• W2066487764 title "Thyroglobulin antibodies in Type 1 diabetic patients and their relatives — measurement with highly sensitive assay" @default.
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• W2066487764 doi "https://doi.org/10.1016/0168-8227(94)90048-5" @default.
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