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• W2066489636 abstract "Formation of the intrinsic tenase complex is an essential event in the procoagulant reactions that lead to clot formation. The tenase complex is formed when the activated serine protease, Factor IXa (FIXa), and its cofactor Factor VIIIa (FVIIIa) assemble on a phospholipid surface to proteolytically convert the zymogen Factor X (FX) into its active form FXa. The physiological relevance of the tenase complex is evident in hemophilia A or B patients who present with bleeding disorders.The purpose of this study was to establish three-dimensional (3D) models of the FVIIIa-FIXa complex.First, we built two new theoretical models of FVIIIa via homology modeling, inter-domain docking and loop simulation algorithms as well as a model for FIXa. This was followed by pseudo-Brownian protein-protein docking in internal coordinates with the ICM (Internal Coordinates Mechanics) program between the two FVIIIa and the FIXa structures.Ten representative models of this complex are presented based on agreements with known experimental data and according to structural criteria.These novel 3D models will help guide future site directed mutagenesis aimed at improving the functionality of FVIIIa and/or FIXa and will contribute to a better understanding of the role of this macromolecular complex in the blood coagulation cascade." @default.
• W2066489636 created "2016-06-24" @default.
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• W2066489636 creator A5080082986 @default.
• W2066489636 creator A5082243444 @default.
• W2066489636 date "2005-09-01" @default.
• W2066489636 modified "2023-10-12" @default.
• W2066489636 title "Molecular models of the procoagulant Factor VIIIa–Factor IXa complex" @default.
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• W2066489636 cites W1494429407 @default.
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• W2066489636 cites W1534532061 @default.
• W2066489636 cites W1548566593 @default.
• W2066489636 cites W1599481463 @default.
• W2066489636 cites W1639776510 @default.
• W2066489636 cites W1872915373 @default.
• W2066489636 cites W1891870091 @default.
• W2066489636 cites W1966009694 @default.
• W2066489636 cites W1969679124 @default.
• W2066489636 cites W1970476675 @default.
• W2066489636 cites W1971784860 @default.
• W2066489636 cites W1973687786 @default.
• W2066489636 cites W1975768977 @default.
• W2066489636 cites W1983294129 @default.
• W2066489636 cites W1992232455 @default.
• W2066489636 cites W1994568170 @default.
• W2066489636 cites W1996983268 @default.
• W2066489636 cites W1999317096 @default.
• W2066489636 cites W2004725960 @default.
• W2066489636 cites W2005651680 @default.
• W2066489636 cites W2008679330 @default.
• W2066489636 cites W2010190573 @default.
• W2066489636 cites W2012163359 @default.
• W2066489636 cites W2014289060 @default.
• W2066489636 cites W2020908798 @default.
• W2066489636 cites W2022686807 @default.
• W2066489636 cites W2023312563 @default.
• W2066489636 cites W2027767811 @default.
• W2066489636 cites W2028843689 @default.
• W2066489636 cites W2029087609 @default.
• W2066489636 cites W2031259648 @default.
• W2066489636 cites W2036444072 @default.
• W2066489636 cites W2038129713 @default.
• W2066489636 cites W2040089859 @default.
• W2066489636 cites W2040644205 @default.
• W2066489636 cites W2041299584 @default.
• W2066489636 cites W2041349540 @default.
• W2066489636 cites W2042555275 @default.
• W2066489636 cites W2047163848 @default.
• W2066489636 cites W2048485197 @default.
• W2066489636 cites W2058369753 @default.
• W2066489636 cites W2058590056 @default.
• W2066489636 cites W2066087726 @default.
• W2066489636 cites W2070616597 @default.
• W2066489636 cites W2073530895 @default.
• W2066489636 cites W2076694118 @default.
• W2066489636 cites W2077210064 @default.
• W2066489636 cites W2077269068 @default.
• W2066489636 cites W2084283788 @default.
• W2066489636 cites W2085342425 @default.
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• W2066489636 cites W2116455136 @default.
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• W2066489636 cites W2121293250 @default.
• W2066489636 cites W2123259277 @default.
• W2066489636 cites W2126265982 @default.
• W2066489636 cites W2130958902 @default.
• W2066489636 cites W2146106891 @default.
• W2066489636 cites W2151300760 @default.
• W2066489636 cites W2152737925 @default.
• W2066489636 cites W2153644601 @default.
• W2066489636 cites W2154181324 @default.
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• W2066489636 cites W2276178845 @default.
• W2066489636 cites W2276193850 @default.
• W2066489636 cites W2283037005 @default.
• W2066489636 cites W2402657668 @default.
• W2066489636 cites W2414027291 @default.
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• W2066489636 doi "https://doi.org/10.1111/j.1538-7836.2005.01527.x" @default.
• W2066489636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16102111" @default.
• W2066489636 hasPublicationYear "2005" @default.
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