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- W2066491510 abstract "Cefetamet is a potent antibiotic to treat respiratory and urinary tract infections. To improve oral bioavailability, it is administered as a prodrug, cefetamet pivoxyl hydrolyzed by esterase following absorption. A quantification method using a mass spectrometry was developed for the determination of cefetamet in human plasma. After a protein precipitation with acetonitrile, the analytes were chromatographed on a reversed-phase C18 column and detected by a tandem mass spectrometer with electrospray ionization. The accuracy and precision of the assay were in accordance with FDA regulations for the validation of bioanalytical methods. This method was used to measure the concentrations of the cefetamet in plasma after a single oral administration of 500 mg cefetamet pivoxyl. Copyright © 2010 John Wiley & Sons, Ltd." @default.
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- W2066491510 date "2010-09-14" @default.
- W2066491510 modified "2023-09-27" @default.
- W2066491510 title "Quantitative determination of cefetamet in human plasma by liquid chromatography-mass spectrometry" @default.
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- W2066491510 doi "https://doi.org/10.1002/bmc.1516" @default.
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