FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066502441> ?p ?o ?g. }

• W2066502441 endingPage "167" @default.
• W2066502441 startingPage "159" @default.
• W2066502441 abstract "The thyrotropin receptor (TSHR) exhibits elevated cAMP signaling in the basal state and becomes fully activated by thyrotropin. Previously we presented evidence that small-molecule ligands act allosterically within the transmembrane region in contrast to the orthosteric extracellular hormone-binding sites. Our goal in this study was to identify positions that surround the allosteric pocket and that are sensitive for inactivation of TSHR. Homology modeling combined with site-directed mutagenesis and functional characterization revealed seven mutants located in the allosteric binding site that led to a decrease of basal cAMP signaling activity. The majority of these silencing mutations, which constrain the TSHR in an inactive conformation, are found in two clusters when mapped onto the 3D structural model. We suggest that the amino acid positions identified herein are indicating locations where small-molecule antagonists, both neutral antagonists and inverse agonists, might interfere with active TSHR conformations." @default.
• W2066502441 created "2016-06-24" @default.
• W2066502441 creator A5005079343 @default.
• W2066502441 creator A5013526268 @default.
• W2066502441 creator A5020668359 @default.
• W2066502441 creator A5023308750 @default.
• W2066502441 creator A5038486817 @default.
• W2066502441 creator A5043849323 @default.
• W2066502441 creator A5055948934 @default.
• W2066502441 creator A5064607856 @default.
• W2066502441 creator A5080093811 @default.
• W2066502441 date "2010-07-22" @default.
• W2066502441 modified "2023-10-09" @default.
• W2066502441 title "Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor" @default.
• W2066502441 cites W1833104430 @default.
• W2066502441 cites W1968153952 @default.
• W2066502441 cites W1970510439 @default.
• W2066502441 cites W1978145192 @default.
• W2066502441 cites W1979665833 @default.
• W2066502441 cites W1979923215 @default.
• W2066502441 cites W1980292173 @default.
• W2066502441 cites W1986208226 @default.
• W2066502441 cites W1988097700 @default.
• W2066502441 cites W1992681029 @default.
• W2066502441 cites W1994977582 @default.
• W2066502441 cites W1998554645 @default.
• W2066502441 cites W1999362670 @default.
• W2066502441 cites W1999942812 @default.
• W2066502441 cites W2004487089 @default.
• W2066502441 cites W2007702516 @default.
• W2066502441 cites W2017495869 @default.
• W2066502441 cites W2023291722 @default.
• W2066502441 cites W2025605951 @default.
• W2066502441 cites W2031343184 @default.
• W2066502441 cites W2033806704 @default.
• W2066502441 cites W2035545569 @default.
• W2066502441 cites W2038101785 @default.
• W2066502441 cites W2038404269 @default.
• W2066502441 cites W2063194349 @default.
• W2066502441 cites W2065868638 @default.
• W2066502441 cites W2069519523 @default.
• W2066502441 cites W2069978572 @default.
• W2066502441 cites W2072370784 @default.
• W2066502441 cites W2072608359 @default.
• W2066502441 cites W2072966398 @default.
• W2066502441 cites W2078676835 @default.
• W2066502441 cites W2091089626 @default.
• W2066502441 cites W2100554558 @default.
• W2066502441 cites W2101978469 @default.
• W2066502441 cites W2111732644 @default.
• W2066502441 cites W2120205802 @default.
• W2066502441 cites W2140740343 @default.
• W2066502441 cites W2141972580 @default.
• W2066502441 cites W2149848264 @default.
• W2066502441 cites W2152982825 @default.
• W2066502441 cites W2155993910 @default.
• W2066502441 cites W2156027990 @default.
• W2066502441 cites W2159186008 @default.
• W2066502441 cites W2262699654 @default.
• W2066502441 cites W2328254412 @default.
• W2066502441 cites W2916372536 @default.
• W2066502441 cites W2952767760 @default.
• W2066502441 doi "https://doi.org/10.1007/s00018-010-0451-2" @default.
• W2066502441 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3099415" @default.
• W2066502441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20652618" @default.
• W2066502441 hasPublicationYear "2010" @default.
• W2066502441 type Work @default.
• W2066502441 sameAs 2066502441 @default.
• W2066502441 citedByCount "26" @default.
• W2066502441 countsByYear W20665024412012 @default.
• W2066502441 countsByYear W20665024412013 @default.
• W2066502441 countsByYear W20665024412014 @default.
• W2066502441 countsByYear W20665024412015 @default.
• W2066502441 countsByYear W20665024412016 @default.
• W2066502441 countsByYear W20665024412017 @default.
• W2066502441 countsByYear W20665024412018 @default.
• W2066502441 countsByYear W20665024412019 @default.
• W2066502441 countsByYear W20665024412020 @default.
• W2066502441 countsByYear W20665024412022 @default.
• W2066502441 countsByYear W20665024412023 @default.
• W2066502441 crossrefType "journal-article" @default.
• W2066502441 hasAuthorship W2066502441A5005079343 @default.
• W2066502441 hasAuthorship W2066502441A5013526268 @default.
• W2066502441 hasAuthorship W2066502441A5020668359 @default.
• W2066502441 hasAuthorship W2066502441A5023308750 @default.
• W2066502441 hasAuthorship W2066502441A5038486817 @default.
• W2066502441 hasAuthorship W2066502441A5043849323 @default.
• W2066502441 hasAuthorship W2066502441A5055948934 @default.
• W2066502441 hasAuthorship W2066502441A5064607856 @default.
• W2066502441 hasAuthorship W2066502441A5080093811 @default.
• W2066502441 hasBestOaLocation W20665024412 @default.
• W2066502441 hasConcept C104317684 @default.
• W2066502441 hasConcept C107824862 @default.
• W2066502441 hasConcept C109964505 @default.
• W2066502441 hasConcept C118892022 @default.
• W2066502441 hasConcept C135285700 @default.
• W2066502441 hasConcept C143065580 @default.
• W2066502441 hasConcept C161624437 @default.

• next