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- W2066505787 abstract "Nigella sativa L. (Ranunculaceae) is considered as a therapeutic plant-based medicine for liver damage. In this study, the aim was to study the effect of Nigella sativa oil (NSO) pretreatment on ethanol-induced hepatotoxicity in rats. Rats were given Nigella sativa oil at doses of 2.5 and 5.0 mL·kg−1, orally for 3 weeks, followed by oral ethanol (EtOH) administration (5 g·kg−1) every 12 h three times (binge model). Binge ethanol application caused significant increases in plasma transaminase activities and hepatic triglyceride and malondialdehyde (MDA) levels. It decreased hepatic glutathione (GSH) levels, but did not change vitamins E and vitamin C levels and antioxidant enzyme activities. NSO (5.0 mL·kg−1) pretreatment significantly decreased plasma transaminase activities, hepatic MDA, and triglyceride levels together with amelioration in hepatic histopathological findings. NSO pretreatment may be effective in protecting oxidative stress-induced hepatotoxicity after ethanol administration" @default.
- W2066505787 created "2016-06-24" @default.
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- W2066505787 date "2014-07-01" @default.
- W2066505787 modified "2023-09-24" @default.
- W2066505787 title "Protective effect of Nigella sativa oil against binge ethanol-induced oxidative stress and liver injury in rats" @default.
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- W2066505787 doi "https://doi.org/10.1016/s1875-5364(14)60077-7" @default.
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