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- W2066525046 abstract "We have characterized a G-protein-coupled glutamate receptor in primary cultures of striatal neurons. Glutamate, quisqualate, or trans-1-aminocyclopentane-1,3-dicarboxylate inhibited by 30-40% either forskolin-stimulated cAMP production in intact cells or forskolin plus vasoactive intestinal peptide-activated adenylyl cyclase assayed in neuronal membrane preparations. These inhibitory effects were suppressed after treatment of striatal neurons with Bordetella pertussis toxin, suggesting the involvement of a heterotrimeric guanine nucleotide-binding protein (G protein) of the G(i)/G(o) subtype. The pharmacological profile of this glutamate receptor negatively coupled to adenylyl cyclase was different from that of the metabotropic Qp glutamate receptor coupled to phospholipase C in striatal neurons and from that of the recently cloned mGluR2 glutamate receptor, which is negatively coupled to adenylyl cyclase when expressed in non-neuronal cells." @default.
- W2066525046 created "2016-06-24" @default.
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- W2066525046 date "1992-09-01" @default.
- W2066525046 modified "2023-10-03" @default.
- W2066525046 title "Characterization of a metabotropic glutamate receptor: direct negative coupling to adenylyl cyclase and involvement of a pertussis toxin-sensitive G protein." @default.
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- W2066525046 doi "https://doi.org/10.1073/pnas.89.17.8040" @default.
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