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- W2066544850 abstract "The suitability of a pulsed dye laser (504 nm) in experimental and clinical angioplasty was investigated. In an experimental study, the ablation thresholds were 3 J/cm<sup>2</sup> ± 8 (mean ± standard deviation) for fibrofatty plaque and 25 J/cm<sup>2</sup> for calcified tissues under saline. At a radiant exposure of 10 J/cm<sup>2</sup> the etch rates were 1.7 μm per pulse ± 0.3 for media, 2.8 μm/pulse ± 0.4 for normal intima, and 3.9 μm/pulse ± 1.1 for fibrofatty plaque (<i>P</i> < .05). Pressure wave effects with a separation of tissue layers were predominantly localized at the internal elastic lamina. Thermal injury with vacuolations extended 15 μm ± 6 into adjacent tissue. For clinical study, laser-assisted balloon angioplasty was performed in 10 patients (64 years ± 14) with occlusions of peripheral arteries using a 9-F multifiber ring catheter. Lesion length ranged from 2 to 12 cm (mean, 7 cm). Laser angioplasty with an 80 mJ/pulse decreased the mean stenosis from 100% to 58% ± 12% (<i>P</i> < .005). The ankle-brachial index rose from a median of 0.48 to 0.88 (<i>P</i> < .001). In 33% of patients, there were subintimal dissections after laser angioplasty. After a mean follow-up of 10.2 months, the overall clinical success was 70% with a primary patency of 78%. The over-the-wire approach with a pulsed dye laser may constitute a safe and feasible tool in laser angioplasty." @default.
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- W2066544850 date "1992-02-01" @default.
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- W2066544850 title "In Vitro and Clinical Feasibility Study with an Over-the-Wire Delivery System for Pulsed Dye Laser Angioplasty" @default.
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- W2066544850 doi "https://doi.org/10.1016/s1051-0443(92)72187-3" @default.
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