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• W2066556542 abstract "As large-scale ivermectin distribution is becoming the mainstay of onchocerciasis control in Africa, the issue of its impact on local transmission is increasing in importance. The vector competence of Simulium squamosum B in the severe focus of the Sanaga valley, Cameroon, was therefore investigated, by feeding 1320 flies on 14 carriers of Onchocerca volvulus microfilariae (mff). The results enabled the relationships between skin microfilarial load, microfilarial intake by the flies, the proportion and mean number of ingested mff that succeed in reaching the fly's haemocoel, and the frequency distribution of the ingested mff to be described, as functions of time post-engorgement (p.e.) and parasite density (while taking account of possible measurement error in the predictor variable). The proportion of flies with haemocoelic mff and the mean number of mff/fly increased up to 3 h p.e. The proportion of flies with ingested mff was non-linearly related to mean intake, via the negative-binomial distribution, with the overdispersion parameter k best described as an increasing (power) function of the mean. Approximately one in every three ingested mff escaped imprisonment by the peritrophic matrix, irrespective of the skin microfilarial load or the intake of mff. The relationship between successful and input mff is nearly linear (indicating proportionality) in S. squamosum B. These results are compared with those from O. volvulus-S. damnosum s.l. combinations in other West African foci." @default.
• W2066556542 created "2016-06-24" @default.
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• W2066556542 date "2003-06-01" @default.
• W2066556542 modified "2023-10-17" @default.
• W2066556542 title "Experimental studies on the transmission of<i>Onchocerca volvulus</i>by its vector in the Sanaga valley (Cameroon):<i>Simulium squamosum</i>B. Intake of microfilariae and their migration to the haemocoel of the vector" @default.
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• W2066556542 doi "https://doi.org/10.1179/000349803235002254" @default.
• W2066556542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12831524" @default.
• W2066556542 hasPublicationYear "2003" @default.
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