Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066558081> ?p ?o ?g. }
- W2066558081 endingPage "320" @default.
- W2066558081 startingPage "315" @default.
- W2066558081 abstract "Rare tautomeric and anionic nucleobases are believed to have fundamental biological roles, but their prevalence and functional importance has remained elusive because they exist transiently, in low abundance, and involve subtle movements of protons that are difficult to visualize. Using NMR relaxation dispersion, we show here that wobble dG•dT and rG•rU mispairs in DNA and RNA duplexes exist in dynamic equilibrium with short-lived, low-populated Watson-Crick-like mispairs that are stabilized by rare enolic or anionic bases. These mispairs can evade Watson-Crick fidelity checkpoints and form with probabilities (10(-3) to 10(-5)) that strongly imply a universal role in replication and translation errors. Our results indicate that rare tautomeric and anionic bases are widespread in nucleic acids, expanding their structural and functional complexity beyond that attainable with canonical bases." @default.
- W2066558081 created "2016-06-24" @default.
- W2066558081 creator A5034049456 @default.
- W2066558081 creator A5053708779 @default.
- W2066558081 creator A5059356621 @default.
- W2066558081 creator A5062272861 @default.
- W2066558081 creator A5091767059 @default.
- W2066558081 date "2015-03-11" @default.
- W2066558081 modified "2023-10-16" @default.
- W2066558081 title "Visualizing transient Watson–Crick-like mispairs in DNA and RNA duplexes" @default.
- W2066558081 cites W1553355802 @default.
- W2066558081 cites W1576472122 @default.
- W2066558081 cites W1594838223 @default.
- W2066558081 cites W1596335359 @default.
- W2066558081 cites W1597138031 @default.
- W2066558081 cites W1767395388 @default.
- W2066558081 cites W1827567297 @default.
- W2066558081 cites W1894612901 @default.
- W2066558081 cites W1940686732 @default.
- W2066558081 cites W1965995198 @default.
- W2066558081 cites W1966776068 @default.
- W2066558081 cites W1967958221 @default.
- W2066558081 cites W1969015817 @default.
- W2066558081 cites W1969425758 @default.
- W2066558081 cites W1971589546 @default.
- W2066558081 cites W1973056448 @default.
- W2066558081 cites W1973488583 @default.
- W2066558081 cites W1974207257 @default.
- W2066558081 cites W1975277407 @default.
- W2066558081 cites W1978034323 @default.
- W2066558081 cites W1982985581 @default.
- W2066558081 cites W1983129879 @default.
- W2066558081 cites W1983167449 @default.
- W2066558081 cites W1983559907 @default.
- W2066558081 cites W1986532301 @default.
- W2066558081 cites W1989487251 @default.
- W2066558081 cites W1991330225 @default.
- W2066558081 cites W1996717928 @default.
- W2066558081 cites W1998162994 @default.
- W2066558081 cites W2002703964 @default.
- W2066558081 cites W2007059663 @default.
- W2066558081 cites W2009013836 @default.
- W2066558081 cites W2011753511 @default.
- W2066558081 cites W2014849398 @default.
- W2066558081 cites W2015047001 @default.
- W2066558081 cites W2015436959 @default.
- W2066558081 cites W2018712554 @default.
- W2066558081 cites W2021626702 @default.
- W2066558081 cites W2026514619 @default.
- W2066558081 cites W2029704872 @default.
- W2066558081 cites W2031536080 @default.
- W2066558081 cites W2031808936 @default.
- W2066558081 cites W2035200998 @default.
- W2066558081 cites W2037435041 @default.
- W2066558081 cites W2046018697 @default.
- W2066558081 cites W2046065232 @default.
- W2066558081 cites W2046187908 @default.
- W2066558081 cites W2047192699 @default.
- W2066558081 cites W2052246375 @default.
- W2066558081 cites W2052831849 @default.
- W2066558081 cites W2054829368 @default.
- W2066558081 cites W2055557864 @default.
- W2066558081 cites W2060905099 @default.
- W2066558081 cites W2061869689 @default.
- W2066558081 cites W2067810191 @default.
- W2066558081 cites W2070723598 @default.
- W2066558081 cites W2074295796 @default.
- W2066558081 cites W2074703703 @default.
- W2066558081 cites W2078070626 @default.
- W2066558081 cites W2084295374 @default.
- W2066558081 cites W2086359829 @default.
- W2066558081 cites W2093728891 @default.
- W2066558081 cites W2103903051 @default.
- W2066558081 cites W2113766528 @default.
- W2066558081 cites W2117430673 @default.
- W2066558081 cites W2118531126 @default.
- W2066558081 cites W2126780661 @default.
- W2066558081 cites W2127674396 @default.
- W2066558081 cites W2127753323 @default.
- W2066558081 cites W2128911048 @default.
- W2066558081 cites W2135253292 @default.
- W2066558081 cites W2137948699 @default.
- W2066558081 cites W2150697053 @default.
- W2066558081 cites W2152112318 @default.
- W2066558081 cites W2161130060 @default.
- W2066558081 cites W2167231685 @default.
- W2066558081 cites W2169821755 @default.
- W2066558081 cites W2170474431 @default.
- W2066558081 cites W2318596598 @default.
- W2066558081 cites W2319034102 @default.
- W2066558081 cites W24311317 @default.
- W2066558081 doi "https://doi.org/10.1038/nature14227" @default.
- W2066558081 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4547696" @default.
- W2066558081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25762137" @default.
- W2066558081 hasPublicationYear "2015" @default.
- W2066558081 type Work @default.
- W2066558081 sameAs 2066558081 @default.
- W2066558081 citedByCount "208" @default.