Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066562597> ?p ?o ?g. }
- W2066562597 endingPage "2018" @default.
- W2066562597 startingPage "2003" @default.
- W2066562597 abstract "The incidence of type 2 diabetes mellitus (T2DM) has risen to epidemic proportions, and this is associated with enormous cost. T2DM is preceded by 'prediabetes', and the diagnosis of impaired glucose tolerance (IGT) and/or impaired fasting glucose (IFG) provides an opportunity for targeted intervention. Prediabetic subjects manifest both core defects characteristic of T2DM, that is, insulin resistance and β-cell dysfunction. Interventions which improve insulin sensitivity and/or preserve β-cell function are logical strategies to delay the conversion of IGT/IFG to T2DM or revert glucose tolerance to normal.The authors examine pharmacologic agents that have proven to decrease the conversion of IGT to T2DM and represent potential treatment options in prediabetes.Weight loss improves whole body insulin sensitivity, preserves β-cell function and decreases progression of prediabetes to T2DM. In real life long-term weight loss is the exception and, even if successful, 40 - 50% of IGT individuals still progress to T2DM. Pharmacotherapy provides an alternative strategy to improve insulin sensitivity and preserve β-cell function. Thiazolidinediones (TZDs) are highly effective in T2DM prevention. Long-acting glucagon-like peptide-1 (GLP-1) analogs, because they augment β-cell function and promote weight loss, are effective in preventing IGT progression to T2DM. Metformin is considerably less effective than TZDs or GLP-1 analogs." @default.
- W2066562597 created "2016-06-24" @default.
- W2066562597 creator A5005726509 @default.
- W2066562597 creator A5076218609 @default.
- W2066562597 creator A5091912602 @default.
- W2066562597 date "2014-08-19" @default.
- W2066562597 modified "2023-10-16" @default.
- W2066562597 title "What are the pharmacotherapy options for treating prediabetes?" @default.
- W2066562597 cites W11872906 @default.
- W2066562597 cites W121348928 @default.
- W2066562597 cites W1967295307 @default.
- W2066562597 cites W1969550954 @default.
- W2066562597 cites W1974893245 @default.
- W2066562597 cites W1975588287 @default.
- W2066562597 cites W1975591028 @default.
- W2066562597 cites W1975663485 @default.
- W2066562597 cites W1978288432 @default.
- W2066562597 cites W1978897192 @default.
- W2066562597 cites W1981101443 @default.
- W2066562597 cites W1981456793 @default.
- W2066562597 cites W1981581852 @default.
- W2066562597 cites W1982880468 @default.
- W2066562597 cites W1984297603 @default.
- W2066562597 cites W1984513597 @default.
- W2066562597 cites W1984740259 @default.
- W2066562597 cites W1991778481 @default.
- W2066562597 cites W1992505070 @default.
- W2066562597 cites W1992777999 @default.
- W2066562597 cites W1992788957 @default.
- W2066562597 cites W1994299902 @default.
- W2066562597 cites W1994320162 @default.
- W2066562597 cites W1994768261 @default.
- W2066562597 cites W2001192679 @default.
- W2066562597 cites W2005507128 @default.
- W2066562597 cites W2006625394 @default.
- W2066562597 cites W2009918956 @default.
- W2066562597 cites W2009969219 @default.
- W2066562597 cites W2015279471 @default.
- W2066562597 cites W2023663637 @default.
- W2066562597 cites W2029228033 @default.
- W2066562597 cites W2033116294 @default.
- W2066562597 cites W2033125833 @default.
- W2066562597 cites W2033524876 @default.
- W2066562597 cites W2034721926 @default.
- W2066562597 cites W2034864533 @default.
- W2066562597 cites W2038823716 @default.
- W2066562597 cites W2044960566 @default.
- W2066562597 cites W2045068495 @default.
- W2066562597 cites W2051018841 @default.
- W2066562597 cites W2053609205 @default.
- W2066562597 cites W2053990917 @default.
- W2066562597 cites W2058922633 @default.
- W2066562597 cites W2059503876 @default.
- W2066562597 cites W2061524651 @default.
- W2066562597 cites W2062560800 @default.
- W2066562597 cites W2067710447 @default.
- W2066562597 cites W2068953741 @default.
- W2066562597 cites W2070710390 @default.
- W2066562597 cites W2072989847 @default.
- W2066562597 cites W2075647580 @default.
- W2066562597 cites W2076921335 @default.
- W2066562597 cites W2077149049 @default.
- W2066562597 cites W2078089300 @default.
- W2066562597 cites W2080070851 @default.
- W2066562597 cites W2080509628 @default.
- W2066562597 cites W2081276121 @default.
- W2066562597 cites W2082032596 @default.
- W2066562597 cites W2083120140 @default.
- W2066562597 cites W2084948079 @default.
- W2066562597 cites W2085588685 @default.
- W2066562597 cites W2087674201 @default.
- W2066562597 cites W2088160164 @default.
- W2066562597 cites W2089304685 @default.
- W2066562597 cites W2089437710 @default.
- W2066562597 cites W2094083143 @default.
- W2066562597 cites W2097309757 @default.
- W2066562597 cites W2101702701 @default.
- W2066562597 cites W2103930636 @default.
- W2066562597 cites W2105719905 @default.
- W2066562597 cites W2107037013 @default.
- W2066562597 cites W2109420598 @default.
- W2066562597 cites W2109728760 @default.
- W2066562597 cites W2109961081 @default.
- W2066562597 cites W2111184067 @default.
- W2066562597 cites W2112677603 @default.
- W2066562597 cites W2113544353 @default.
- W2066562597 cites W2113586416 @default.
- W2066562597 cites W2115161226 @default.
- W2066562597 cites W2115433418 @default.
- W2066562597 cites W2117057656 @default.
- W2066562597 cites W2119114384 @default.
- W2066562597 cites W2121264929 @default.
- W2066562597 cites W2121879147 @default.
- W2066562597 cites W2122623377 @default.
- W2066562597 cites W2123472586 @default.
- W2066562597 cites W2123744385 @default.
- W2066562597 cites W2123946565 @default.
- W2066562597 cites W2124477479 @default.