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• W2066580839 abstract "was to investigate the in vivo and in vitro cardiovascular activity of a procyanidin fraction (PCF) obtained from acetone extract of Guazuma ulmifolia bark which has traditionally been used as an antihypertensive agent. 10 mg/kg PCF doses orally administered to sugar-fed hypertensive rats decreased both the systolic arterial pressure and the heart rate, whereas the same doses intravenously administered induced arterial hypotension which was attenuated by NG-nitro-l-arginine methylester (L-NAME 31 mg/kg) pretreatment. In these experiments we employed carbachol as a positive control test. The PCF reduced the contraction induced by norepinephrine (1 × 10−7 M) in isolated aortic rings of normotensive (IC50 = 35.3 ± 12.4 ng/mL) and sugar-fed hypertensive (IC50 = 101.3 ± 57.2 ng/mL) rats. This relaxant activity was inhibited by either vascular endothelium removal or L-NAME (30 μM) pretreatment, while indomethacin (10 μM) or atropine (10 μM) had no effect. Preliminary analysis of the PCF by HPLC–DAD–MS and FAB+ mass spectrometry allowed the detection of the main components such as the complex of procyanidin oligomers consisting mainly of tetramers and trimers. Guazuma ulmifolia bark possesses long-lasting antihypertensive and vasorelaxing properties linked to the endothelium related factors, where nitric oxide is involved." @default.
• W2066580839 created "2016-06-24" @default.
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• W2066580839 date "2008-04-01" @default.
• W2066580839 modified "2023-10-18" @default.
• W2066580839 title "Hypotensive and vasorelaxant effects of the procyanidin fraction from Guazuma ulmifolia bark in normotensive and hypertensive rats" @default.
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• W2066580839 doi "https://doi.org/10.1016/j.jep.2008.01.015" @default.
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