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- W2066611491 abstract "microRNAs (miRNAs) are a conserved class of small RNAs ∼22 nucleotides in length. They regulate the expression of a large number of mRNAs in animals and plants through the miRNA-induced silencing complex (miRISC). The conserved GW182 family of proteins has recently been identified, and its members have been shown to be associated with miRISC and to be required for miRNA-mediated gene silencing. These proteins have also been localized to processing bodies that are cytoplasmic messenger ribonucleoprotein (mRNP) aggregates containing mRNA decay factors, translational repressors and untranslated mRNAs. Therefore, these properties of GW182 family proteins support the hypothesis that the formation of untranslatable messenger ribonuclear protein particles is one important mechanism of miRNA-mediated gene silencing." @default.
- W2066611491 created "2016-06-24" @default.
- W2066611491 creator A5004096220 @default.
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- W2066611491 date "2007-08-01" @default.
- W2066611491 modified "2023-10-14" @default.
- W2066611491 title "GW182 family proteins are crucial for microRNA-mediated gene silencing" @default.
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- W2066611491 doi "https://doi.org/10.1016/j.tcb.2007.06.003" @default.
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