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- W2066626276 abstract "A novel class of 5,6-dihydro-4H-benzo[d]isoxazol-7-ones and 5,6-dihydro-4H-isoxazolo[5,4-c]pyridin-7-ones was designed, synthesized, and assayed to investigate the affinity toward Hsp90 protein. The synthetic route was based on a 1,3-dipolar cycloaddition of nitriloxides, generated in situ from suitable benzaldoximes, with 2-bromocyclohex-2-enones or 3-bromo-5,6-dihydro-1H-pyridin-2-ones. Whereas all the compounds bearing a benzamide group on the bicyclic scaffold were devoid of activity, the derivatives carrying a resorcinol-like fragment showed a remarkable inhibitory effect on Hsp90. Docking calculations were performed to investigate the orientation of the new compounds within the binding site of the enzyme." @default.
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- W2066626276 date "2015-04-30" @default.
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- W2066626276 title "Synthesis of 5,6-dihydro-4<i>H</i> -benzo[<i>d</i> ]isoxazol-7-one and 5,6-dihydro-4<i>H</i> -isoxazolo[5,4-<i>c</i> ]pyridin-7-one Derivatives as Potential Hsp90 Inhibitors" @default.
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- W2066626276 doi "https://doi.org/10.1111/cbdd.12570" @default.
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