FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066632961> ?p ?o ?g. }

• W2066632961 endingPage "1172" @default.
• W2066632961 startingPage "1162" @default.
• W2066632961 abstract "Experiments were conducted to assess ischemia-induced reperfusion injury in the pig latissimus dorsi myocutaneous flap model. Forty Yorkshire pigs (19.5 ± 0.6 kg) were assigned to groups A, B, C, and D (n = 10 pigs). Bilateral 8 × 13 cm latissimus dorsi myocutaneous flaps were constructed in each pig, and one flap was assigned to ischemic treatment and the contralateral flap served as a nonischemic control. The treatment flaps in groups A, B, C, and D were subjected to 2, 4, 6, and 8 hours of warm global ischemia, respectively. Pigs in groups A, B, C, and D were divided into two subgroups (n = 5 pigs), and extents of skin and muscle necrosis in control and treatment flaps were assessed with the fluorescein and nitroblue tetrazolium dye stain tests, respectively, after 2 and 7 days of reperfusion. Significantly (p < 0.01) greater extents of skin and muscle necrosis were observed in latissimus dorsi myocutaneous flaps subjected to 4, 6, or 8 hours of ischemia compared with their contralateral controls. Extents of skin and muscle necrosis also increased significantly (p < 0.01) with increases in ischemia time in treatment flaps. Of particular importance was the observation that there was no significant difference in the extent of skin or muscle necrosis between 2 and 7 days of reperfusion in all control and treatment groups. This observation indicates that 2 days of reperfusion time is adequate to assess the maximum extent of skin and muscle ischemia-induced reperfusion injury in pig latissimus dorsi myocutaneous flaps. Furthermore, it was observed that 1-cm segments of latissimus dorsi muscle were not too thick to allow the use of the nitroblue tetrazolium dye stain test for assessment of muscle viability, as judged by the highly correlated (r = 0.98, n = 40) linear relationship between assessment of muscle viability from one transverse cut surface of muscle segments and by weighing total viable and nonviable muscles dissected from the flaps according to the nitroblue tetrazolium dye stain on both transverse cut surfaces. It is important to note that the maximum length of the latissimus dorsi myocutaneous flap model for ischemia-induced reperfusion injury research should not exceed the maximum length of skin viability in the nonischemic control in order to avoid the complication of skin necrosis due to excessive length of skin. The pattern of muscle necrosis revealed by nitroblue tetrazolium dye staining indicated that muscle necrosis occurred mainly and consistently in the proximal dorsal portion of the latissimus dorsi myocutaneous flap, where the muscle was the thickest, thus permitting easy access for multiple muscle biopsies without significant damage to the flap. Histologic study revealed that the pig latissimus dorsi muscle was composed of types I(19 percent) and II (81 percent) muscle fibers. There was no observable indication of difference in tolerance of ischemia-induced reperfusion injury between these two types of fibers because the nitroblue tetrazolium dye stain was quite uniform in the viable and nonviable areas of the latissimus dorsi muscle. The technical information obtained from the present experiments is important when using the pig latissimus dorsi myocutaneous flap model to study the pathophysiology and pharmacology of ischemia-induced reperfusion injury in myocutaneous flaps." @default.
• W2066632961 created "2016-06-24" @default.
• W2066632961 creator A5020848796 @default.
• W2066632961 creator A5033004595 @default.
• W2066632961 creator A5036917842 @default.
• W2066632961 creator A5079186174 @default.
• W2066632961 creator A5086649095 @default.
• W2066632961 date "1993-11-01" @default.
• W2066632961 modified "2023-10-16" @default.
• W2066632961 title "Assessment of Ischemia-Induced Reperfusion Injury in the Pig Latissimus Dorsi Myocutaneous Flap Model" @default.
• W2066632961 doi "https://doi.org/10.1097/00006534-199311000-00026" @default.
• W2066632961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8234514" @default.
• W2066632961 hasPublicationYear "1993" @default.
• W2066632961 type Work @default.
• W2066632961 sameAs 2066632961 @default.
• W2066632961 citedByCount "48" @default.
• W2066632961 countsByYear W20666329612013 @default.
• W2066632961 countsByYear W20666329612014 @default.
• W2066632961 countsByYear W20666329612015 @default.
• W2066632961 countsByYear W20666329612016 @default.
• W2066632961 countsByYear W20666329612017 @default.
• W2066632961 countsByYear W20666329612019 @default.
• W2066632961 countsByYear W20666329612020 @default.
• W2066632961 countsByYear W20666329612022 @default.
• W2066632961 countsByYear W20666329612023 @default.
• W2066632961 crossrefType "journal-article" @default.
• W2066632961 hasAuthorship W2066632961A5020848796 @default.
• W2066632961 hasAuthorship W2066632961A5033004595 @default.
• W2066632961 hasAuthorship W2066632961A5036917842 @default.
• W2066632961 hasAuthorship W2066632961A5079186174 @default.
• W2066632961 hasAuthorship W2066632961A5086649095 @default.
• W2066632961 hasConcept C126322002 @default.
• W2066632961 hasConcept C141071460 @default.
• W2066632961 hasConcept C142724271 @default.
• W2066632961 hasConcept C2780114680 @default.
• W2066632961 hasConcept C2780552095 @default.
• W2066632961 hasConcept C2991913917 @default.
• W2066632961 hasConcept C42219234 @default.
• W2066632961 hasConcept C503630168 @default.
• W2066632961 hasConcept C541997718 @default.
• W2066632961 hasConcept C71924100 @default.
• W2066632961 hasConceptScore W2066632961C126322002 @default.
• W2066632961 hasConceptScore W2066632961C141071460 @default.
• W2066632961 hasConceptScore W2066632961C142724271 @default.
• W2066632961 hasConceptScore W2066632961C2780114680 @default.
• W2066632961 hasConceptScore W2066632961C2780552095 @default.
• W2066632961 hasConceptScore W2066632961C2991913917 @default.
• W2066632961 hasConceptScore W2066632961C42219234 @default.
• W2066632961 hasConceptScore W2066632961C503630168 @default.
• W2066632961 hasConceptScore W2066632961C541997718 @default.
• W2066632961 hasConceptScore W2066632961C71924100 @default.
• W2066632961 hasIssue "6" @default.
• W2066632961 hasLocation W20666329611 @default.
• W2066632961 hasLocation W20666329612 @default.
• W2066632961 hasOpenAccess W2066632961 @default.
• W2066632961 hasPrimaryLocation W20666329611 @default.
• W2066632961 hasRelatedWork W1969074099 @default.
• W2066632961 hasRelatedWork W2029394706 @default.
• W2066632961 hasRelatedWork W2037001060 @default.
• W2066632961 hasRelatedWork W2074623876 @default.
• W2066632961 hasRelatedWork W2363406581 @default.
• W2066632961 hasRelatedWork W2364428879 @default.
• W2066632961 hasRelatedWork W2376757330 @default.
• W2066632961 hasRelatedWork W2380390685 @default.
• W2066632961 hasRelatedWork W2394179638 @default.
• W2066632961 hasRelatedWork W3032570139 @default.
• W2066632961 hasVolume "92" @default.
• W2066632961 isParatext "false" @default.
• W2066632961 isRetracted "false" @default.
• W2066632961 magId "2066632961" @default.
• W2066632961 workType "article" @default.