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- W2066636245 abstract "Resveratrol, a phytoalexin present in the skin of grapes and red wine, has been demonstrated to possess a wide range of health promoting activities including anti-diabetic properties. In the present study, we investigated the effect of resveratrol in both type 2 diabetic mice and cell culture systems. In cultured L6 myotubes, we studied the effect of resveratrol on glucose uptake and translocation of glucose transporter 4 to plasma membrane from the aspects of insulin signaling and AMP-activated protein kinase signaling. In cultured RIN-5F cells, we examined whether resveratrol would protect the pancreas-derived β-cells from oxidative stress. Resveratrol significantly suppressed the elevation in the fasting blood glucose level and the serum triglyceride and lipid peroxide levels in db/db mice. Resveratrol stimulated glucose uptake and glucose transporter 4 translocation by activating both insulin signaling and AMP-activated protein kinase signaling. Moreover, resveratrol could protect pancreatic β-cells from advanced glycation end products-induced oxidative stress and apoptosis. From these results, resveratrol is suggested to show anti-diabetic effect by stimulating both insulin-dependent and -independent glucose uptake in muscles and by protecting pancreatic β-cells from advanced glycation end products-induced oxidative stress and apoptosis." @default.
- W2066636245 created "2016-06-24" @default.
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- W2066636245 date "2011-01-01" @default.
- W2066636245 modified "2023-10-17" @default.
- W2066636245 title "Hypoglycemic effect of resveratrol in type 2 diabetic model db/db mice and its actions in cultured L6 myotubes and RIN-5F pancreatic β-cells" @default.
- W2066636245 cites W180946569 @default.
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- W2066636245 cites W1984830754 @default.
- W2066636245 cites W1987443462 @default.
- W2066636245 cites W1988848089 @default.
- W2066636245 cites W1992317935 @default.
- W2066636245 cites W1996626295 @default.
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- W2066636245 doi "https://doi.org/10.3164/jcbn.10-119" @default.
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