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- W2066645234 endingPage "H2219" @default.
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- W2066645234 abstract "The ubiquitin-proteasome system (UPS) is responsible for the degradation of most cellular proteins. Alterations in cardiac UPS, including changes in the degradation of regulatory proteins and proteasome functional insufficiency, are observed in many forms of heart disease and have been shown to play an important role in cardiac pathogenesis. In the past several years, remarkable progress in understanding the mechanisms that regulate UPS-mediated protein degradation has been achieved. A transgenic mouse model of benign enhancement of cardiac proteasome proteolytic function has been created. This has led to the first demonstration of the necessity of proteasome functional insufficiency in the genesis of important pathological processes. Cardiomyocyte-restricted enhancement of proteasome proteolytic function by overexpression of proteasome activator 28α protects against cardiac proteinopathy and myocardial ischemia-reperfusion injury. Additionally, exciting advances have recently been achieved in the search for a pharmacological agent to activate the proteasome. These breakthroughs are expected to serve as an impetus to further investigation into the involvement of UPS dysfunction in molecular pathogenesis and to the development of new therapeutic strategies for combating heart disease. An interplay between the UPS and macroautophagy is increasingly suggested in noncardiac systems but is not well understood in the cardiac system. Further investigations into the interplay are expected to provide a more comprehensive picture of cardiac protein quality control and degradation." @default.
- W2066645234 created "2016-06-24" @default.
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- W2066645234 date "2011-12-01" @default.
- W2066645234 modified "2023-09-28" @default.
- W2066645234 title "Proteasome functional insufficiency in cardiac pathogenesis" @default.
- W2066645234 cites W1503691982 @default.
- W2066645234 cites W1503901149 @default.
- W2066645234 cites W1561566743 @default.
- W2066645234 cites W1623206089 @default.
- W2066645234 cites W1965575777 @default.
- W2066645234 cites W1966007989 @default.
- W2066645234 cites W1967108243 @default.
- W2066645234 cites W1967159107 @default.
- W2066645234 cites W1968975143 @default.
- W2066645234 cites W1970228194 @default.
- W2066645234 cites W1971857747 @default.
- W2066645234 cites W1975482510 @default.
- W2066645234 cites W1978745673 @default.
- W2066645234 cites W1978979379 @default.
- W2066645234 cites W1979566598 @default.
- W2066645234 cites W1979775299 @default.
- W2066645234 cites W1980124970 @default.
- W2066645234 cites W1982314662 @default.
- W2066645234 cites W1982982813 @default.
- W2066645234 cites W1983211817 @default.
- W2066645234 cites W1983592427 @default.
- W2066645234 cites W1984854176 @default.
- W2066645234 cites W1985959978 @default.
- W2066645234 cites W1986023077 @default.
- W2066645234 cites W1987011447 @default.
- W2066645234 cites W1988513665 @default.
- W2066645234 cites W1991000990 @default.
- W2066645234 cites W1991198986 @default.
- W2066645234 cites W1991558827 @default.
- W2066645234 cites W1992618521 @default.
- W2066645234 cites W1993561057 @default.
- W2066645234 cites W1994823455 @default.
- W2066645234 cites W1995687168 @default.
- W2066645234 cites W1999506204 @default.
- W2066645234 cites W2000091638 @default.
- W2066645234 cites W2004954349 @default.
- W2066645234 cites W2005997790 @default.
- W2066645234 cites W2007050986 @default.
- W2066645234 cites W2007277647 @default.
- W2066645234 cites W2008020112 @default.
- W2066645234 cites W2011780976 @default.
- W2066645234 cites W2012296420 @default.
- W2066645234 cites W2014376812 @default.
- W2066645234 cites W2014888545 @default.
- W2066645234 cites W2014889227 @default.
- W2066645234 cites W2015777977 @default.
- W2066645234 cites W2016727777 @default.
- W2066645234 cites W2018357999 @default.
- W2066645234 cites W2022812113 @default.
- W2066645234 cites W2023598683 @default.
- W2066645234 cites W2024627774 @default.
- W2066645234 cites W2025665129 @default.
- W2066645234 cites W2025858860 @default.
- W2066645234 cites W2029633430 @default.
- W2066645234 cites W2031414922 @default.
- W2066645234 cites W2033797333 @default.
- W2066645234 cites W2035074494 @default.
- W2066645234 cites W2035094622 @default.
- W2066645234 cites W2036903182 @default.
- W2066645234 cites W2040798958 @default.
- W2066645234 cites W2044757757 @default.
- W2066645234 cites W2044876445 @default.
- W2066645234 cites W2047033624 @default.
- W2066645234 cites W2049360602 @default.
- W2066645234 cites W2051641469 @default.
- W2066645234 cites W2053505300 @default.
- W2066645234 cites W2054554887 @default.
- W2066645234 cites W2057233739 @default.
- W2066645234 cites W2058192005 @default.
- W2066645234 cites W2058727367 @default.
- W2066645234 cites W2060946137 @default.
- W2066645234 cites W2061301580 @default.
- W2066645234 cites W2061588397 @default.
- W2066645234 cites W2062629975 @default.
- W2066645234 cites W2068134926 @default.
- W2066645234 cites W2068894929 @default.
- W2066645234 cites W2069866232 @default.
- W2066645234 cites W2070254246 @default.
- W2066645234 cites W2072994817 @default.
- W2066645234 cites W2076194625 @default.
- W2066645234 cites W2076856334 @default.
- W2066645234 cites W2078379844 @default.
- W2066645234 cites W2082441148 @default.
- W2066645234 cites W2083644948 @default.
- W2066645234 cites W2086176678 @default.
- W2066645234 cites W2086717365 @default.
- W2066645234 cites W2086906489 @default.
- W2066645234 cites W2089748347 @default.