FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066648049> ?p ?o ?g. }

• W2066648049 endingPage "1077" @default.
• W2066648049 startingPage "1066" @default.
• W2066648049 abstract "Cetuximab is an epidermal growth factor receptor (EGFR)-blocking antibody that is approved to treat several types of solid cancers in patients. We recently showed that cetuximab can induce autophagy in cancer cells by both inhibiting the class I phosphatidylinositol 3-kinase (PtdIns3K)/Akt/mammalian target of rapamycin (mTOR) pathway and activating the class III PtdIns3K (hVps34)/beclin 1 pathway. In the current study, we investigated the relationship between cetuximab-induced autophagy and apoptosis and the biological roles of autophagy in cetuximab-mediated cancer therapy. We found that cetuximab induced autophagy in cancer cells that show strong or weak induction of apoptosis after cetuximab treatment but not in those that show only cytostatic growth inhibition. Inhibition of cetuximab-induced apoptosis by a caspase inhibitor prevented the induction of autophagy. Conversely, inhibition of cetuximab-induced autophagy by silencing the expression of autophagy-related genes (Atg) or treating the cancer cells with lysosomal inhibitors enhanced the cetuximab-induced apoptosis, suggesting that autophagy was a protective cellular response to cetuximab treatment. On the other hand, cotreatment of cancer cells with cetuximab and the mTOR inhibitor rapamycin resulted in an Atg-dependent and lysosomal inhibition-sensitive death of cancer cells that show only growth inhibition or weak apoptosis after cetuximab treatment, indicating that cell death may be achieved by activating the autophagy pathway in these cells. Together, our findings may guide the development of novel clinical strategies for sensitizing cancer cells to EGFR-targeted therapy." @default.
• W2066648049 created "2016-06-24" @default.
• W2066648049 creator A5041087415 @default.
• W2066648049 creator A5043084593 @default.
• W2066648049 creator A5062635617 @default.
• W2066648049 creator A5062951448 @default.
• W2066648049 date "2010-11-16" @default.
• W2066648049 modified "2023-10-16" @default.
• W2066648049 title "Roles of autophagy in cetuximab-mediated cancer therapy against EGFR" @default.
• W2066648049 cites W1560977824 @default.
• W2066648049 cites W1796205058 @default.
• W2066648049 cites W1964421187 @default.
• W2066648049 cites W1977767269 @default.
• W2066648049 cites W1987005832 @default.
• W2066648049 cites W1987695408 @default.
• W2066648049 cites W1995580879 @default.
• W2066648049 cites W2003887174 @default.
• W2066648049 cites W2017855147 @default.
• W2066648049 cites W2025128734 @default.
• W2066648049 cites W2027727753 @default.
• W2066648049 cites W2033351371 @default.
• W2066648049 cites W2038882649 @default.
• W2066648049 cites W2042455211 @default.
• W2066648049 cites W2048006212 @default.
• W2066648049 cites W2057458801 @default.
• W2066648049 cites W2086895849 @default.
• W2066648049 cites W2092999710 @default.
• W2066648049 cites W2095213976 @default.
• W2066648049 cites W2096441944 @default.
• W2066648049 cites W2097097666 @default.
• W2066648049 cites W2104850613 @default.
• W2066648049 cites W2107693250 @default.
• W2066648049 cites W2108086395 @default.
• W2066648049 cites W2121075882 @default.
• W2066648049 cites W2129712803 @default.
• W2066648049 cites W2142350279 @default.
• W2066648049 cites W2145206598 @default.
• W2066648049 cites W2149388384 @default.
• W2066648049 cites W2153653048 @default.
• W2066648049 cites W2155305458 @default.
• W2066648049 cites W2156320420 @default.
• W2066648049 cites W2157824687 @default.
• W2066648049 cites W2159809160 @default.
• W2066648049 cites W2167656141 @default.
• W2066648049 cites W4211075026 @default.
• W2066648049 doi "https://doi.org/10.4161/auto.6.8.13366" @default.
• W2066648049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3039478" @default.
• W2066648049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20864811" @default.
• W2066648049 hasPublicationYear "2010" @default.
• W2066648049 type Work @default.
• W2066648049 sameAs 2066648049 @default.
• W2066648049 citedByCount "84" @default.
• W2066648049 countsByYear W20666480492012 @default.
• W2066648049 countsByYear W20666480492013 @default.
• W2066648049 countsByYear W20666480492014 @default.
• W2066648049 countsByYear W20666480492015 @default.
• W2066648049 countsByYear W20666480492016 @default.
• W2066648049 countsByYear W20666480492017 @default.
• W2066648049 countsByYear W20666480492018 @default.
• W2066648049 countsByYear W20666480492019 @default.
• W2066648049 countsByYear W20666480492020 @default.
• W2066648049 countsByYear W20666480492021 @default.
• W2066648049 countsByYear W20666480492022 @default.
• W2066648049 countsByYear W20666480492023 @default.
• W2066648049 crossrefType "journal-article" @default.
• W2066648049 hasAuthorship W2066648049A5041087415 @default.
• W2066648049 hasAuthorship W2066648049A5043084593 @default.
• W2066648049 hasAuthorship W2066648049A5062635617 @default.
• W2066648049 hasAuthorship W2066648049A5062951448 @default.
• W2066648049 hasBestOaLocation W20666480491 @default.
• W2066648049 hasConcept C121608353 @default.
• W2066648049 hasConcept C190283241 @default.
• W2066648049 hasConcept C203522944 @default.
• W2066648049 hasConcept C2779438470 @default.
• W2066648049 hasConcept C2779998722 @default.
• W2066648049 hasConcept C31573885 @default.
• W2066648049 hasConcept C502942594 @default.
• W2066648049 hasConcept C526805850 @default.
• W2066648049 hasConcept C54355233 @default.
• W2066648049 hasConcept C55493867 @default.
• W2066648049 hasConcept C75217442 @default.
• W2066648049 hasConcept C86554907 @default.
• W2066648049 hasConcept C86803240 @default.
• W2066648049 hasConcept C96232424 @default.
• W2066648049 hasConceptScore W2066648049C121608353 @default.
• W2066648049 hasConceptScore W2066648049C190283241 @default.
• W2066648049 hasConceptScore W2066648049C203522944 @default.
• W2066648049 hasConceptScore W2066648049C2779438470 @default.
• W2066648049 hasConceptScore W2066648049C2779998722 @default.
• W2066648049 hasConceptScore W2066648049C31573885 @default.
• W2066648049 hasConceptScore W2066648049C502942594 @default.
• W2066648049 hasConceptScore W2066648049C526805850 @default.
• W2066648049 hasConceptScore W2066648049C54355233 @default.
• W2066648049 hasConceptScore W2066648049C55493867 @default.
• W2066648049 hasConceptScore W2066648049C75217442 @default.
• W2066648049 hasConceptScore W2066648049C86554907 @default.
• W2066648049 hasConceptScore W2066648049C86803240 @default.
• W2066648049 hasConceptScore W2066648049C96232424 @default.

• next