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• W2066656751 abstract "Adrenergic (C1) neurons located in the rostral ventrolateral medulla are considered a key component in the control of arterial blood pressure. Classically, C1 cells have been identified by their immunoreactivity for the catecholamine biosynthetic enzymes tyrosine hydroxylase (TH) and/or phenylethanolamine N-methyltransferase (PNMT). However, no studies have simultaneously demonstrated the expression of aromatic L-amino acid decarboxylase (AADC) and dopamine β-hydroxylase (DBH) in these neurons. We examined the expression and colocalization of all four enzymes in the rat ventrolateral medulla using immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) analysis. Retrograde tracer injected into thoracic spinal segments T2–T4 was used to identify bulbospinal neurons. Using fluorescence and confocal microscopy, most cells of the C1 group were shown to be double or triple labeled with TH, DBH, and PNMT, whereas only 65–78% were immunoreactive for AADC. Cells that lacked detectable immunoreactivity for AADC were located in the rostral C1 region, and approximately 50% were spinally projecting. Some cells in this area lacked DBH immunoreactivity (6.5–8.3%) but were positive for TH and/or PNMT. Small numbers of cells were immunoreactive for only one of the four enzymes. Numerous fibres that were immunoreactive for DBH but not for TH or PNMT were noted in the rostral C1 region. Single-cell RT-PCR analysis conducted on spinally projecting C1 neurons indicated that only 76.5% of cells that contained mRNA for TH, DBH, and PNMT contained detectable message for AADC. These experiments suggest that a proportion of C1 cells may not express all of the enzymes necessary for adrenaline synthesis. J. Comp. Neurol. 432:20–34, 2001. © 2001 Wiley-Liss, Inc." @default.
• W2066656751 created "2016-06-24" @default.
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• W2066656751 date "2001-01-01" @default.
• W2066656751 modified "2023-10-12" @default.
• W2066656751 title "Differential expression of catecholamine biosynthetic enzymes in the rat ventrolateral medulla" @default.
• W2066656751 cites W1852824492 @default.
• W2066656751 cites W1956230030 @default.
• W2066656751 cites W1958669289 @default.
• W2066656751 cites W1966464425 @default.
• W2066656751 cites W1967966913 @default.
• W2066656751 cites W1968568694 @default.
• W2066656751 cites W1976119196 @default.
• W2066656751 cites W1976226020 @default.
• W2066656751 cites W1979754912 @default.
• W2066656751 cites W1980817649 @default.
• W2066656751 cites W1981450341 @default.
• W2066656751 cites W1983059448 @default.
• W2066656751 cites W1984240004 @default.
• W2066656751 cites W1988341578 @default.
• W2066656751 cites W1990356750 @default.
• W2066656751 cites W1996694096 @default.
• W2066656751 cites W1997686227 @default.
• W2066656751 cites W1998084858 @default.
• W2066656751 cites W2005760144 @default.
• W2066656751 cites W2015788237 @default.
• W2066656751 cites W2018170514 @default.
• W2066656751 cites W2021703462 @default.
• W2066656751 cites W2022788181 @default.
• W2066656751 cites W2023605292 @default.
• W2066656751 cites W2026010953 @default.
• W2066656751 cites W2026596420 @default.
• W2066656751 cites W2026969553 @default.
• W2066656751 cites W2032190306 @default.
• W2066656751 cites W2033081954 @default.
• W2066656751 cites W2037595770 @default.
• W2066656751 cites W2047843802 @default.
• W2066656751 cites W2049427971 @default.
• W2066656751 cites W2050237055 @default.
• W2066656751 cites W2051173988 @default.
• W2066656751 cites W2053544520 @default.
• W2066656751 cites W2053810272 @default.
• W2066656751 cites W2055149383 @default.
• W2066656751 cites W2055177303 @default.
• W2066656751 cites W2056978249 @default.
• W2066656751 cites W2057005298 @default.
• W2066656751 cites W2059360432 @default.
• W2066656751 cites W2059813761 @default.
• W2066656751 cites W2060517770 @default.
• W2066656751 cites W2062801220 @default.
• W2066656751 cites W2063465801 @default.
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• W2066656751 cites W2081917000 @default.
• W2066656751 cites W2083570580 @default.
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• W2066656751 cites W2086583753 @default.
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• W2066656751 cites W2106196012 @default.
• W2066656751 cites W2130076902 @default.
• W2066656751 cites W2155615145 @default.
• W2066656751 cites W2161825101 @default.
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• W2066656751 doi "https://doi.org/10.1002/cne.1086" @default.
• W2066656751 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11241375" @default.
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