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• W2066657777 abstract "Population structure can be a source of both false-positive and false-negative findings in a genome-wide association study. This article proposes an approach that helps to reduce the false-positives. It consists of homogenizing the diseased/healthy phenotype ratio across the cohort, by decreasing the statistical weight of selected individuals. After homogenization, the cohort is statistically handled as if originating from a single well-mixed population. The method was applied to homogenize a Parkinson's disease genome-wide association study cohort." @default.
• W2066657777 created "2016-06-24" @default.
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• W2066657777 date "2012-10-29" @default.
• W2066657777 modified "2023-10-15" @default.
• W2066657777 title "Genome-Wide Association Study Heterogeneous Cohort Homogenization via Subject Weight Knock-Down" @default.
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• W2066657777 doi "https://doi.org/10.1371/journal.pone.0048653" @default.
• W2066657777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3483272" @default.
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