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- W2066658698 abstract "Parabens are widely used as preservatives in food, cosmetic and pharmaceutical products. Acute, subchronic, and chronic studies in rodents indicate that parabens are practically non-toxic. Parabens are rapidly absorbed, metabolized, and excreted. In individuals with normal skin, parabens are, for the most part, non-irritating and non-sensitizing. However, application of compounds containing parabens to damaged or broken skin has resulted in sensitization. Genotoxicity testing of parabens in a variety of in vitro and in vivo studies primarily gave negative results. The paraben structure is not indicative of carcinogenic potential, and experimental studies support these observations. Some animal studies have reported adverse reproductive effects of parabens. In an uterotrophic assay, methyl and butyl paraben administered orally to immature rats were inactive, while subcutaneous administration of butyl paraben produced a weak positive response. The ability of parabens to transactivate the estrogen receptor in vitro increases with alkyl group size. The detection of parabens in a small number of breast tumor tissue samples and adverse reproductive effects of parabens in animals has provoked controversy over the continued use of these substances. However, the possible estrogenic hazard of parabens on the basis of the available studies is equivocal, and fails to consider the metabolism and elimination rates of parabens, which are dose, route, and species dependent. In light of the recent controversy over the estrogenic potential of parabens, conduct of a reproductive toxicity study may be warranted." @default.
- W2066658698 created "2016-06-24" @default.
- W2066658698 creator A5027936259 @default.
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- W2066658698 date "2005-07-01" @default.
- W2066658698 modified "2023-10-16" @default.
- W2066658698 title "Safety assessment of esters of p-hydroxybenzoic acid (parabens)" @default.
- W2066658698 cites W1536149315 @default.
- W2066658698 cites W1592289571 @default.
- W2066658698 cites W1872680748 @default.
- W2066658698 cites W1949715899 @default.
- W2066658698 cites W1963575908 @default.
- W2066658698 cites W1966989031 @default.
- W2066658698 cites W1967152830 @default.
- W2066658698 cites W1968227278 @default.
- W2066658698 cites W1969311624 @default.
- W2066658698 cites W1969516876 @default.
- W2066658698 cites W1970247015 @default.
- W2066658698 cites W1972609440 @default.
- W2066658698 cites W1973371801 @default.
- W2066658698 cites W1973799301 @default.
- W2066658698 cites W1974079015 @default.
- W2066658698 cites W1974811370 @default.
- W2066658698 cites W1975688052 @default.
- W2066658698 cites W1975954034 @default.
- W2066658698 cites W1976917904 @default.
- W2066658698 cites W1980511347 @default.
- W2066658698 cites W1983278103 @default.
- W2066658698 cites W1985608733 @default.
- W2066658698 cites W1986953635 @default.
- W2066658698 cites W1987012783 @default.
- W2066658698 cites W1987504546 @default.
- W2066658698 cites W1988928063 @default.
- W2066658698 cites W1989287146 @default.
- W2066658698 cites W1990695727 @default.
- W2066658698 cites W1999057925 @default.
- W2066658698 cites W2003795095 @default.
- W2066658698 cites W2004970442 @default.
- W2066658698 cites W2005430846 @default.
- W2066658698 cites W2006241929 @default.
- W2066658698 cites W2006587480 @default.
- W2066658698 cites W2008672761 @default.
- W2066658698 cites W2011230073 @default.
- W2066658698 cites W2015739077 @default.
- W2066658698 cites W2017237442 @default.
- W2066658698 cites W2017423831 @default.
- W2066658698 cites W2017452196 @default.
- W2066658698 cites W2022609085 @default.
- W2066658698 cites W2022961232 @default.
- W2066658698 cites W2023458314 @default.
- W2066658698 cites W2024245620 @default.
- W2066658698 cites W2024704171 @default.
- W2066658698 cites W2026053667 @default.
- W2066658698 cites W2027252506 @default.
- W2066658698 cites W2029018242 @default.
- W2066658698 cites W2029135262 @default.
- W2066658698 cites W2030434094 @default.
- W2066658698 cites W2032642391 @default.
- W2066658698 cites W2033959503 @default.
- W2066658698 cites W2034295101 @default.
- W2066658698 cites W2034445566 @default.
- W2066658698 cites W2036070199 @default.
- W2066658698 cites W2036256406 @default.
- W2066658698 cites W2041830684 @default.
- W2066658698 cites W2042954070 @default.
- W2066658698 cites W2043083896 @default.
- W2066658698 cites W2043676939 @default.
- W2066658698 cites W2043867178 @default.
- W2066658698 cites W2049513648 @default.
- W2066658698 cites W2049891008 @default.
- W2066658698 cites W2049953303 @default.
- W2066658698 cites W2051027596 @default.
- W2066658698 cites W2051367670 @default.
- W2066658698 cites W2054205645 @default.
- W2066658698 cites W2059540439 @default.
- W2066658698 cites W2061603952 @default.
- W2066658698 cites W2062881175 @default.
- W2066658698 cites W2064618435 @default.
- W2066658698 cites W2065281578 @default.
- W2066658698 cites W2066080882 @default.
- W2066658698 cites W2068130137 @default.
- W2066658698 cites W2068685127 @default.
- W2066658698 cites W2070785107 @default.
- W2066658698 cites W2071512901 @default.
- W2066658698 cites W2071682800 @default.
- W2066658698 cites W2072066001 @default.
- W2066658698 cites W2078983776 @default.
- W2066658698 cites W2079358955 @default.
- W2066658698 cites W2079913794 @default.
- W2066658698 cites W2080444436 @default.
- W2066658698 cites W2080917393 @default.
- W2066658698 cites W2080941028 @default.
- W2066658698 cites W2081622766 @default.
- W2066658698 cites W2083219894 @default.
- W2066658698 cites W2083625124 @default.
- W2066658698 cites W2083996316 @default.
- W2066658698 cites W2085375026 @default.