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• W2066659898 abstract "<h3>Objective</h3> To determine the association between inflammatory markers and change in knee pain over 5 years. <h3>Methods</h3> A total of 149 randomly selected subjects (mean 63 years, range 52–78; 46% female) was studied. Serum levels of high sensitivity C-reactive protein (hs-CRP), tumour necrosis factor alpha (TNF–α) and interleukin (IL)-6 were measured at baseline and 2.7 years later. Knee pain was recorded using the Western Ontario and McMasters osteoarthritis index questionnaire at baseline and 5 years later. Knee radiographic osteoarthritis of both knees was assessed at baseline, and knee bone marrow lesions, joint effusion and cartilage defects were determined using T1 or T2-weighted fat saturated MRI. <h3>Results</h3> After adjustment for confounding variables, baseline hs-CRP was positively associated with change in total knee pain (β=0.33 per mg/l, p=0.032), as well as change in the pain at night in bed (β=0.12 per ml/pg, p=0.010) and while sitting/lying (β=0.12 per ml/pg, p=0.002). Change in hs-CRP was also associated with change in knee pain at night and when sitting/lying (both p<0.05). Baseline TNFα and IL-6 were associated with change in pain while standing (β=0.06 per ml/pg, p=0.033; β=0.16 per ml/pg, p=0.035, respectively), and change in TNFα was positively associated with change in total knee pain (β=0.66 ml/pg, p=0.020) and change in pain while standing (β=0.26 ml/pg, p=0.002). Adjustment for radiographic osteoarthritis or MRI-detected structural abnormalities led to no or minor attenuation of these associations. <h3>Conclusion</h3> Systemic inflammation is an independent predictor of worsening knee pain over 5 years." @default.
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• W2066659898 date "2012-05-12" @default.
• W2066659898 modified "2023-09-29" @default.
• W2066659898 title "Associations between serum levels of inflammatory markers and change in knee pain over 5 years in older adults: a prospective cohort study" @default.
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• W2066659898 doi "https://doi.org/10.1136/annrheumdis-2011-201047" @default.
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