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• W2066666287 abstract "The N-myc gene is amplified and overexpressed in neuroblastoma, retinoblastoma and small cell lung carcinoma, and is considered to be related to cell proliferation and/or differentiation. The transcriptional regulatory sequences of the c-myc gene have been already identified, while those of N-myc have remained obscure for a long time. In this report, we have identified several positive and negative transcriptional regulatory elements in the upstream region of the mouse N-myc gene. Among them, an activating sequence spanning -860 to -797 bp (63 bp) could be reduced to a functional core of 21 bp from -846 to -826. This sequence, termed N21 box, worked as a positive transcriptional element when linked directly upstream (but not downstream) of the putative N-myc promoter in HeLa, not in IMR32 cells. At least two proteins, of 42 kDa and 100 kDa, bound to the double-stranded N21 box, and were expressed in HeLa as well as in IMR32 cells. Moreover, the plus strand of N21 box could be specifically bound by a species of 42 kDa from either cell type and by a 37 kDa protein found only in HeLa cells. These proteins may be factors binding to positive transcriptional regulatory elements and may have a role in the regulation of N-myc expression." @default.
• W2066666287 created "2016-06-24" @default.
• W2066666287 creator A5000059241 @default.
• W2066666287 creator A5028043877 @default.
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• W2066666287 date "1993-11-01" @default.
• W2066666287 modified "2023-09-23" @default.
• W2066666287 title "Transcriptional regulation of the N-myc gene: Identification of positive regulatory element and its double- and single-stranded DNA binding proteins" @default.
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• W2066666287 doi "https://doi.org/10.1016/0167-4781(93)90154-6" @default.
• W2066666287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8241268" @default.
• W2066666287 hasPublicationYear "1993" @default.
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