FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066670801> ?p ?o ?g. }

• W2066670801 endingPage "918" @default.
• W2066670801 startingPage "910" @default.
• W2066670801 abstract "Aims NT-proBNP-guided therapy results in intensification of medical heart failure (HF) therapy and is suggested to improve outcome. However, it is feared that an intensified, NT-proBNP-guided therapy carries a risk of adverse effects. Therefore, the safety and tolerability of NT-proBNP-guided therapy in the Trial of Intensified vs standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF) was assessed. Methods and results A total of 495 chronic HF patients, aged ≥60, with an LVEF ≤45%, NYHA class ≥II, randomized to NT-proBNP-guided or symptom-guided therapy and ≥1 month follow-up were included in the present safety analysis. All adverse events (AEs) were recorded during the 18-month trial period. A total of 5212 AEs were noted, 433 of them serious. NT-proBNP-guided therapy led to a higher up-titration of HF medication and was well tolerated, with a dropout rate (12% vs. 11%, P = 1.0) and AE profile [number of AEs/patient-year 4.7 (2.8–9.4) vs. 5.4 (2.7–11.4), P = 0.69; number of severe AEs/patient-year 0.7 (0–2.7) vs. 1.3 (0–3.9), P = 0.21] similar to that of symptom-guided therapy, although most subjects in both treatment groups (96% vs. 95%, P = 0.55) experienced at least one AE. Age and number of co-morbidities were associated with AEs and interacted with the safety profile of NT-proBNP-guided therapy: positive effects were more frequent in younger and less co-morbid patients whereas potential negative effects—although small and related to non-severe AEs only—were only seen in the older and more co-morbid patients. Conclusions NT-proBNP-guided therapy is safe in elderly and highly co-morbid HF patients. Trial registration ISRCTN43596477" @default.
• W2066670801 created "2016-06-24" @default.
• W2066670801 creator A5016301313 @default.
• W2066670801 creator A5024369914 @default.
• W2066670801 creator A5037780761 @default.
• W2066670801 creator A5038603473 @default.
• W2066670801 creator A5042061361 @default.
• W2066670801 creator A5044848112 @default.
• W2066670801 creator A5045259457 @default.
• W2066670801 creator A5053779611 @default.
• W2066670801 creator A5064723825 @default.
• W2066670801 creator A5078302229 @default.
• W2066670801 creator A5078911998 @default.
• W2066670801 date "2013-08-01" @default.
• W2066670801 modified "2023-10-17" @default.
• W2066670801 title "Safety and tolerability of intensified, N‐terminal pro brain natriuretic peptide‐guided compared with standard medical therapy in elderly patients with congestive heart failure: results from TIME‐CHF" @default.
• W2066670801 cites W14674810 @default.
• W2066670801 cites W1910579 @default.
• W2066670801 cites W1988088876 @default.
• W2066670801 cites W1995354197 @default.
• W2066670801 cites W2004779219 @default.
• W2066670801 cites W2007276450 @default.
• W2066670801 cites W2009192001 @default.
• W2066670801 cites W2017666800 @default.
• W2066670801 cites W2025378694 @default.
• W2066670801 cites W2040387703 @default.
• W2066670801 cites W2047758661 @default.
• W2066670801 cites W2061040965 @default.
• W2066670801 cites W2062844209 @default.
• W2066670801 cites W2066228805 @default.
• W2066670801 cites W2068109937 @default.
• W2066670801 cites W2077678288 @default.
• W2066670801 cites W2078574423 @default.
• W2066670801 cites W2081050571 @default.
• W2066670801 cites W2095056452 @default.
• W2066670801 cites W2111945961 @default.
• W2066670801 cites W2120561016 @default.
• W2066670801 cites W2125184590 @default.
• W2066670801 cites W2137534212 @default.
• W2066670801 cites W2138847202 @default.
• W2066670801 cites W2140980422 @default.
• W2066670801 cites W2142768873 @default.
• W2066670801 cites W2160820228 @default.
• W2066670801 cites W22496758 @default.
• W2066670801 cites W2353476948 @default.
• W2066670801 cites W3023363600 @default.
• W2066670801 cites W4293872547 @default.
• W2066670801 cites W4376595924 @default.
• W2066670801 doi "https://doi.org/10.1093/eurjhf/hft079" @default.
• W2066670801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23666681" @default.
• W2066670801 hasPublicationYear "2013" @default.
• W2066670801 type Work @default.
• W2066670801 sameAs 2066670801 @default.
• W2066670801 citedByCount "20" @default.
• W2066670801 countsByYear W20666708012013 @default.
• W2066670801 countsByYear W20666708012014 @default.
• W2066670801 countsByYear W20666708012015 @default.
• W2066670801 countsByYear W20666708012016 @default.
• W2066670801 countsByYear W20666708012017 @default.
• W2066670801 countsByYear W20666708012019 @default.
• W2066670801 countsByYear W20666708012020 @default.
• W2066670801 crossrefType "journal-article" @default.
• W2066670801 hasAuthorship W2066670801A5016301313 @default.
• W2066670801 hasAuthorship W2066670801A5024369914 @default.
• W2066670801 hasAuthorship W2066670801A5037780761 @default.
• W2066670801 hasAuthorship W2066670801A5038603473 @default.
• W2066670801 hasAuthorship W2066670801A5042061361 @default.
• W2066670801 hasAuthorship W2066670801A5044848112 @default.
• W2066670801 hasAuthorship W2066670801A5045259457 @default.
• W2066670801 hasAuthorship W2066670801A5053779611 @default.
• W2066670801 hasAuthorship W2066670801A5064723825 @default.
• W2066670801 hasAuthorship W2066670801A5078302229 @default.
• W2066670801 hasAuthorship W2066670801A5078911998 @default.
• W2066670801 hasBestOaLocation W20666708011 @default.
• W2066670801 hasConcept C126322002 @default.
• W2066670801 hasConcept C164705383 @default.
• W2066670801 hasConcept C168563851 @default.
• W2066670801 hasConcept C197934379 @default.
• W2066670801 hasConcept C2775915353 @default.
• W2066670801 hasConcept C2778198053 @default.
• W2066670801 hasConcept C2778375690 @default.
• W2066670801 hasConcept C71924100 @default.
• W2066670801 hasConcept C78085059 @default.
• W2066670801 hasConceptScore W2066670801C126322002 @default.
• W2066670801 hasConceptScore W2066670801C164705383 @default.
• W2066670801 hasConceptScore W2066670801C168563851 @default.
• W2066670801 hasConceptScore W2066670801C197934379 @default.
• W2066670801 hasConceptScore W2066670801C2775915353 @default.
• W2066670801 hasConceptScore W2066670801C2778198053 @default.
• W2066670801 hasConceptScore W2066670801C2778375690 @default.
• W2066670801 hasConceptScore W2066670801C71924100 @default.
• W2066670801 hasConceptScore W2066670801C78085059 @default.
• W2066670801 hasIssue "8" @default.
• W2066670801 hasLocation W20666708011 @default.
• W2066670801 hasLocation W20666708012 @default.
• W2066670801 hasOpenAccess W2066670801 @default.
• W2066670801 hasPrimaryLocation W20666708011 @default.
• W2066670801 hasRelatedWork W2051712573 @default.

• next