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- W2066671330 abstract "Thalidomide is an effective treatment for relapsed multiple myeloma (MM), but is associated with a significant side effect profile at higher doses. In a recent study, only half of the enrolled patients were able to tolerate the maximum dose of 800 mg/day [Singhal, S., et al. (1999) Antitumor activity of thalidomide in refractory multiple myeloma, New Engl. J. Med. 341, 1565-1571]. Moreover, the dose-response relationship has not been defined. We report our use of low dose thalidomide in a small cohort of 12 patients-eight with relapsed or refractory MM and four with plasma cell leukaemia (PCL). Five of the 12 (42%) patients had a partial response, showing a median fall in their PP/BJP of 80% (63-90%) at a median dose of 175 mg (100-300 mg) with negligible side effects. Three of four patients with PCL showed an impressive response to treatment with thalidomide as a single agent. No patient who failed to show any evidence of response at low dose (<150 mg/day) responded to higher doses. In this study, thalidomide induces a similar rate of response at a lower and better tolerated dose than previously reported and produced best ever responses in patients with resistant PCL." @default.
- W2066671330 created "2016-06-24" @default.
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- W2066671330 date "2002-01-01" @default.
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- W2066671330 title "Thalidomide in Low Doses is Effective for the Treatment of Resistant or Relapsed Multiple Myeloma and for Plasma Cell Leukaemia" @default.
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- W2066671330 doi "https://doi.org/10.1080/10428190290006143" @default.
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