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- W2066675802 abstract "Herpes simplex virus (HSV) stromal keratitis is a leading cause of corneal opacification and an important indication for penetrating keratoplasty. Based on several observational studies and clinical trials, the current standard of care includes topical corticosteroids and antivirals. However, corticosteroids have significant side effects, and antivirals are only beneficial if replicating virus is present. High-quality clinical trials investigating therapies for HSV stromal keratitis beyond corticosteroids and antivirals are lacking. Immune regulatory drugs, such as cyclosporine A, present attractive alternatives to managing HSV stromal keratitis, given the immune-mediated pathogenesis of stromal disease. Also, inhibiting viral reactivation in the latently infected ganglia through therapeutic vaccination will likely be the most efficient avenue to reduce recurrent HSV ocular disease. Our present aim is to review the current evidence-based treatment options for HSV stromal keratitis including and beyond the use of corticosteroids and antivirals and to cultivate insights into developing therapeutic vaccination strategies to inhibit HSV stromal keratitis recurrences." @default.
- W2066675802 created "2016-06-24" @default.
- W2066675802 creator A5009409231 @default.
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- W2066675802 date "2009-03-01" @default.
- W2066675802 modified "2023-10-17" @default.
- W2066675802 title "Management of Herpes Simplex Virus Stromal Keratitis: An Evidence-based Review" @default.
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- W2066675802 cites W1669950918 @default.
- W2066675802 cites W193955673 @default.
- W2066675802 cites W1944135917 @default.
- W2066675802 cites W1963816826 @default.
- W2066675802 cites W1969144061 @default.
- W2066675802 cites W1969287320 @default.
- W2066675802 cites W1969971113 @default.
- W2066675802 cites W1970341165 @default.
- W2066675802 cites W1971842293 @default.
- W2066675802 cites W1973682675 @default.
- W2066675802 cites W1980498795 @default.
- W2066675802 cites W1982070824 @default.
- W2066675802 cites W1986868882 @default.
- W2066675802 cites W1989970916 @default.
- W2066675802 cites W1995796039 @default.
- W2066675802 cites W2000177786 @default.
- W2066675802 cites W2000687651 @default.
- W2066675802 cites W2001581120 @default.
- W2066675802 cites W2012340192 @default.
- W2066675802 cites W2017442092 @default.
- W2066675802 cites W2020722287 @default.
- W2066675802 cites W2021067115 @default.
- W2066675802 cites W2021490494 @default.
- W2066675802 cites W2022190591 @default.
- W2066675802 cites W2022808200 @default.
- W2066675802 cites W2024438032 @default.
- W2066675802 cites W2031970976 @default.
- W2066675802 cites W2033522791 @default.
- W2066675802 cites W2036624344 @default.
- W2066675802 cites W2037471566 @default.
- W2066675802 cites W2044301435 @default.
- W2066675802 cites W2046001743 @default.
- W2066675802 cites W2047932917 @default.
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- W2066675802 cites W2052274546 @default.
- W2066675802 cites W2062520454 @default.
- W2066675802 cites W2065069982 @default.
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- W2066675802 cites W2070011953 @default.
- W2066675802 cites W2071262537 @default.
- W2066675802 cites W2073795225 @default.
- W2066675802 cites W2076993187 @default.
- W2066675802 cites W2079178312 @default.
- W2066675802 cites W2083781121 @default.
- W2066675802 cites W2084676524 @default.
- W2066675802 cites W2086573312 @default.
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- W2066675802 cites W2087390755 @default.
- W2066675802 cites W2087787237 @default.
- W2066675802 cites W2091935320 @default.
- W2066675802 cites W2093464386 @default.
- W2066675802 cites W2093700540 @default.
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- W2066675802 cites W2108794906 @default.
- W2066675802 cites W2111546909 @default.
- W2066675802 cites W2123090800 @default.
- W2066675802 cites W2127033380 @default.
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- W2066675802 cites W2130714678 @default.
- W2066675802 cites W2137248299 @default.
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- W2066675802 cites W2162144034 @default.
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- W2066675802 cites W4229977137 @default.
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- W2066675802 doi "https://doi.org/10.1016/j.survophthal.2008.12.004" @default.
- W2066675802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19298901" @default.
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