FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066679153> ?p ?o ?g. }

• W2066679153 endingPage "22076" @default.
• W2066679153 startingPage "22069" @default.
• W2066679153 abstract "Phosphorylation-dependent ubiquitination and degradation of the IFNAR1 chain of type I interferon (IFN) receptor is a robust and specific mechanism that limits the magnitude and duration of IFNα/β signaling. Besides the ligand-inducible IFNAR1 degradation, the existence of an inside-out signaling that accelerates IFNAR1 turnover in the cells undergoing the endoplasmic reticulum (ER) stress and activated unfolded protein responses has been recently described. The latter pathway does not require either presence of ligands (IFNα/β) or catalytic activity of Janus kinases (JAK). Instead, this pathway relies on activation of the PKR-like ER kinase (PERK) and ensuing specific priming phosphorylation of IFNAR1. Here, we describe studies that identify the stress activated p38 protein kinase as an important regulator of IFNAR1 that acts downstream of PERK. Results of the experiments using pharmacologic p38 kinase inhibitors, RNA interference approach, and cells from p38α knock-out mice suggest that p38 kinase activity is required for priming phosphorylation of IFNAR1 in cells undergoing unfolded protein response. We further demonstrate an important role of p38 kinase in the ligand-independent stimulation of IFNAR1 ubiquitination and degradation and ensuing attenuation of IFNα/β signaling and anti-viral defenses. We discuss the distinct importance of p38 kinase in regulating the overall responses to type I IFN in cells that have been already exposed to IFNα/β versus those cells that are yet to encounter these cytokines." @default.
• W2066679153 created "2016-06-24" @default.
• W2066679153 creator A5013600050 @default.
• W2066679153 creator A5034292648 @default.
• W2066679153 creator A5035025572 @default.
• W2066679153 creator A5061192514 @default.
• W2066679153 creator A5076213121 @default.
• W2066679153 creator A5082801249 @default.
• W2066679153 creator A5091065261 @default.
• W2066679153 date "2011-06-01" @default.
• W2066679153 modified "2023-10-01" @default.
• W2066679153 title "Role of p38 Protein Kinase in the Ligand-independent Ubiquitination and Down-regulation of the IFNAR1 Chain of Type I Interferon Receptor" @default.
• W2066679153 cites W1968134447 @default.
• W2066679153 cites W1971692313 @default.
• W2066679153 cites W1980059815 @default.
• W2066679153 cites W1984960756 @default.
• W2066679153 cites W1986570146 @default.
• W2066679153 cites W1989752867 @default.
• W2066679153 cites W1989773068 @default.
• W2066679153 cites W1994828005 @default.
• W2066679153 cites W1994879373 @default.
• W2066679153 cites W2004547943 @default.
• W2066679153 cites W2007525154 @default.
• W2066679153 cites W2014879168 @default.
• W2066679153 cites W2017405330 @default.
• W2066679153 cites W2019665042 @default.
• W2066679153 cites W2020591967 @default.
• W2066679153 cites W2028867134 @default.
• W2066679153 cites W2029010559 @default.
• W2066679153 cites W2041106589 @default.
• W2066679153 cites W2043188148 @default.
• W2066679153 cites W2047182217 @default.
• W2066679153 cites W2056618213 @default.
• W2066679153 cites W2059380100 @default.
• W2066679153 cites W2060345138 @default.
• W2066679153 cites W2060745847 @default.
• W2066679153 cites W2072754204 @default.
• W2066679153 cites W2078844752 @default.
• W2066679153 cites W2080901528 @default.
• W2066679153 cites W2096931514 @default.
• W2066679153 cites W2097262511 @default.
• W2066679153 cites W2098664515 @default.
• W2066679153 cites W2103565638 @default.
• W2066679153 cites W2109095539 @default.
• W2066679153 cites W2112385479 @default.
• W2066679153 cites W2112435732 @default.
• W2066679153 cites W2121419898 @default.
• W2066679153 cites W2125100593 @default.
• W2066679153 cites W2128513949 @default.
• W2066679153 cites W2128657750 @default.
• W2066679153 cites W2144099695 @default.
• W2066679153 cites W2148810559 @default.
• W2066679153 cites W2152126682 @default.
• W2066679153 cites W2160313021 @default.
• W2066679153 cites W2165310182 @default.
• W2066679153 cites W2167621312 @default.
• W2066679153 cites W2168687405 @default.
• W2066679153 cites W2168943979 @default.
• W2066679153 cites W2186283978 @default.
• W2066679153 cites W4243512717 @default.
• W2066679153 cites W4313343327 @default.
• W2066679153 cites W81053947 @default.
• W2066679153 doi "https://doi.org/10.1074/jbc.m111.238766" @default.
• W2066679153 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3121351" @default.
• W2066679153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21540188" @default.
• W2066679153 hasPublicationYear "2011" @default.
• W2066679153 type Work @default.
• W2066679153 sameAs 2066679153 @default.
• W2066679153 citedByCount "41" @default.
• W2066679153 countsByYear W20666791532012 @default.
• W2066679153 countsByYear W20666791532013 @default.
• W2066679153 countsByYear W20666791532014 @default.
• W2066679153 countsByYear W20666791532015 @default.
• W2066679153 countsByYear W20666791532016 @default.
• W2066679153 countsByYear W20666791532017 @default.
• W2066679153 countsByYear W20666791532018 @default.
• W2066679153 countsByYear W20666791532019 @default.
• W2066679153 countsByYear W20666791532020 @default.
• W2066679153 countsByYear W20666791532021 @default.
• W2066679153 countsByYear W20666791532022 @default.
• W2066679153 countsByYear W20666791532023 @default.
• W2066679153 crossrefType "journal-article" @default.
• W2066679153 hasAuthorship W2066679153A5013600050 @default.
• W2066679153 hasAuthorship W2066679153A5034292648 @default.
• W2066679153 hasAuthorship W2066679153A5035025572 @default.
• W2066679153 hasAuthorship W2066679153A5061192514 @default.
• W2066679153 hasAuthorship W2066679153A5076213121 @default.
• W2066679153 hasAuthorship W2066679153A5082801249 @default.
• W2066679153 hasAuthorship W2066679153A5091065261 @default.
• W2066679153 hasBestOaLocation W20666791531 @default.
• W2066679153 hasConcept C104317684 @default.
• W2066679153 hasConcept C11960822 @default.
• W2066679153 hasConcept C124160383 @default.
• W2066679153 hasConcept C139447449 @default.
• W2066679153 hasConcept C158617107 @default.
• W2066679153 hasConcept C161238802 @default.
• W2066679153 hasConcept C184235292 @default.
• W2066679153 hasConcept C203014093 @default.

• next