Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066680260> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2066680260 endingPage "413" @default.
- W2066680260 startingPage "391" @default.
- W2066680260 abstract "A simple model for a regulatory enzyme is described which leads to relationships between the initial velocity of the catalysed reaction and the varied concentration of a substrate that are of the non-inflected or sigmoidal varieties without a maximum. The model assumes that the most relevant measure of protein configuration (itself determining the kinetic behaviour of the enzyme) is the apparent association constant, αi, measured for the given fractional saturation of the ligand under investigation. It is further assumed that the original state of the protein in solution, α0, is destabilized by an increment of energy, ΔGp0, that is proportional to the fractional saturation of the enzyme by ligand so that the formation of a new configurational state, a,, can be represented by −ΔGp0 = RT ln α1α0. The rate or fractional saturation equation that can be derived from this model predicts both positive and negative cooperativity. Either equation can be transformed for linear representation, provided the maximum velocity or its equivalent maximum saturation is known, and estimates of α0 and αi (the apparent association constants at zero and complete saturation) can be obtained thereby. A procedure is also described by which an initial estimate of the maximum velocity or saturation can be improved. The model is tested by application to a range of data in the literature and it is shown to give fits to the data comparable in quality to those provided by the model of Monod, Wyman & Changeux (1965)." @default.
- W2066680260 created "2016-06-24" @default.
- W2066680260 creator A5002864089 @default.
- W2066680260 date "1977-10-01" @default.
- W2066680260 modified "2023-09-26" @default.
- W2066680260 title "A simple model for a regulatory enzyme" @default.
- W2066680260 cites W13211621 @default.
- W2066680260 cites W1511922886 @default.
- W2066680260 cites W1528995211 @default.
- W2066680260 cites W1578392322 @default.
- W2066680260 cites W1968243869 @default.
- W2066680260 cites W1972919297 @default.
- W2066680260 cites W1975665135 @default.
- W2066680260 cites W1989484975 @default.
- W2066680260 cites W1996314515 @default.
- W2066680260 cites W1998093640 @default.
- W2066680260 cites W2005392755 @default.
- W2066680260 cites W2028219911 @default.
- W2066680260 cites W2056187546 @default.
- W2066680260 cites W2092620426 @default.
- W2066680260 cites W2106614350 @default.
- W2066680260 cites W2141694624 @default.
- W2066680260 cites W4210895329 @default.
- W2066680260 cites W76089181 @default.
- W2066680260 cites W95270438 @default.
- W2066680260 doi "https://doi.org/10.1016/0022-5193(77)90068-6" @default.
- W2066680260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/599943" @default.
- W2066680260 hasPublicationYear "1977" @default.
- W2066680260 type Work @default.
- W2066680260 sameAs 2066680260 @default.
- W2066680260 citedByCount "22" @default.
- W2066680260 crossrefType "journal-article" @default.
- W2066680260 hasAuthorship W2066680260A5002864089 @default.
- W2066680260 hasConcept C111472728 @default.
- W2066680260 hasConcept C114614502 @default.
- W2066680260 hasConcept C121332964 @default.
- W2066680260 hasConcept C121864883 @default.
- W2066680260 hasConcept C134306372 @default.
- W2066680260 hasConcept C135889238 @default.
- W2066680260 hasConcept C138885662 @default.
- W2066680260 hasConcept C166014724 @default.
- W2066680260 hasConcept C185592680 @default.
- W2066680260 hasConcept C199360897 @default.
- W2066680260 hasConcept C2777027219 @default.
- W2066680260 hasConcept C2780586882 @default.
- W2066680260 hasConcept C33923547 @default.
- W2066680260 hasConcept C37914503 @default.
- W2066680260 hasConcept C41008148 @default.
- W2066680260 hasConcept C55493867 @default.
- W2066680260 hasConcept C62520636 @default.
- W2066680260 hasConcept C97355855 @default.
- W2066680260 hasConcept C9930424 @default.
- W2066680260 hasConceptScore W2066680260C111472728 @default.
- W2066680260 hasConceptScore W2066680260C114614502 @default.
- W2066680260 hasConceptScore W2066680260C121332964 @default.
- W2066680260 hasConceptScore W2066680260C121864883 @default.
- W2066680260 hasConceptScore W2066680260C134306372 @default.
- W2066680260 hasConceptScore W2066680260C135889238 @default.
- W2066680260 hasConceptScore W2066680260C138885662 @default.
- W2066680260 hasConceptScore W2066680260C166014724 @default.
- W2066680260 hasConceptScore W2066680260C185592680 @default.
- W2066680260 hasConceptScore W2066680260C199360897 @default.
- W2066680260 hasConceptScore W2066680260C2777027219 @default.
- W2066680260 hasConceptScore W2066680260C2780586882 @default.
- W2066680260 hasConceptScore W2066680260C33923547 @default.
- W2066680260 hasConceptScore W2066680260C37914503 @default.
- W2066680260 hasConceptScore W2066680260C41008148 @default.
- W2066680260 hasConceptScore W2066680260C55493867 @default.
- W2066680260 hasConceptScore W2066680260C62520636 @default.
- W2066680260 hasConceptScore W2066680260C97355855 @default.
- W2066680260 hasConceptScore W2066680260C9930424 @default.
- W2066680260 hasIssue "3" @default.
- W2066680260 hasLocation W20666802601 @default.
- W2066680260 hasLocation W20666802602 @default.
- W2066680260 hasOpenAccess W2066680260 @default.
- W2066680260 hasPrimaryLocation W20666802601 @default.
- W2066680260 hasRelatedWork W1524265942 @default.
- W2066680260 hasRelatedWork W1887191277 @default.
- W2066680260 hasRelatedWork W2023122624 @default.
- W2066680260 hasRelatedWork W2089310898 @default.
- W2066680260 hasRelatedWork W2334954212 @default.
- W2066680260 hasRelatedWork W2377654403 @default.
- W2066680260 hasRelatedWork W2776018879 @default.
- W2066680260 hasRelatedWork W2951104772 @default.
- W2066680260 hasRelatedWork W3045648531 @default.
- W2066680260 hasRelatedWork W4235288607 @default.
- W2066680260 hasVolume "68" @default.
- W2066680260 isParatext "false" @default.
- W2066680260 isRetracted "false" @default.
- W2066680260 magId "2066680260" @default.
- W2066680260 workType "article" @default.