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- W2066680574 abstract "Integrins are essential protagonists in the complex multistep process of cancer progression and metastasis. We recently reported that lebectin, a novel C-type lectin from Macrovipera lebetina venom, displays an anti-integrin activity. In this study, we extend this observation to lebecetin, a second C-type lectin isolated from the same venom and previously reported as a potent inhibitor of platelet aggregation. Both venom lectins appear to exert their effect on cell adhesion, migration, invasion and proliferation by inhibiting α5β1 and αv-containing integrins. Moreover, the inhibition of α5β1 and αv integrins is likely due to the binding of venom peptides, as both lebectin and lebecetin co-immunoprecipitate with these integrins. Lebectin and lebecetin are thus the first examples of venom C-type lectins inhibiting an integrin other than the collagen receptor α2β1." @default.
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- W2066680574 date "2007-05-01" @default.
- W2066680574 modified "2023-09-25" @default.
- W2066680574 title "Lebectin and lebecetin, two C-type lectins from snake venom, inhibit α5β1 and αv-containing integrins" @default.
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- W2066680574 doi "https://doi.org/10.1016/j.matbio.2007.01.001" @default.
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