Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066682485> ?p ?o ?g. }
- W2066682485 endingPage "170" @default.
- W2066682485 startingPage "163" @default.
- W2066682485 abstract "In order to elucidate the role of mitochondrial dysfunction in paracetamol-induced hepatotoxicity, the effects of paracetamol on the oxygen consumption and ATP content of the isolated perfused rat liver were correlated with parameters of hepatic viability and hepatotoxicity. Paracetamol at 5 g/L reduced the oxygen consumption of the livers by about 80% and hepatic ATP content by 96%. Hepatotoxicity was evident from the nearly complete interruption of bile secretion, a marked release of enzymes [glutamate-pyruvate transaminase (GPT), lactate dehydrogenase (LDH)] in the perfusate, a depletion of hepatic glutathione and an accumulation of calcium in the liver. Paracetamol-induced hepatotoxicity could be prevented completely by using livers from non-fasted rats as well as by addition of fructose to the perfusate of livers from fasted animals. Both treatments resulted in an increased energy supply from anaerobic glycolysis as evidenced by a large release of lactate and pyruvate into the perfusate, but did not inhibit paracetamol-induced decline of oxygen consumption. The decrease in hepatic oxygen consumption depended on the dose of paracetamol and occurred first at a concentration of 0.2 g/L (−10%). LDH and GPT release, on the other hand, was elevated at 2 and 5 g/L and calcium accumulation occurred at 5 g/L paracetamol only. Inhibition of mixed-function oxidases by dithiocarb did not prevent the decrease in oxygen consumption and the resulting hepatic injury induced by paracetamol. The oral administration of the high dose of 5 g/kg paracetamol in vivo to rats exerted strong hepatotoxicity but produced maximal serum levels of 800 mg/L paracetamol only and did not decrease hepatic oxygen consumption as measured in vitro. Our results show that in the isolated perfused rat liver in vitro, only high concentrations of paracetamol can produce “chemical hypoxia” by attacking mitochondria so as to cause hepatic injury. Such high concentrations of paracetamol are not attained in vivo, however. “Chemical hypoxia”, thus, seems not to be relevant to the well-known hepatotoxic action of paracetamol." @default.
- W2066682485 created "2016-06-24" @default.
- W2066682485 creator A5027668355 @default.
- W2066682485 creator A5069829098 @default.
- W2066682485 date "1992-07-01" @default.
- W2066682485 modified "2023-10-17" @default.
- W2066682485 title "The toxicological relevance of paracetamol-induced inhibition of hepatic respiration and ATP depletion" @default.
- W2066682485 cites W1525487916 @default.
- W2066682485 cites W164548000 @default.
- W2066682485 cites W1963862229 @default.
- W2066682485 cites W1972447616 @default.
- W2066682485 cites W2008857800 @default.
- W2066682485 cites W2013832046 @default.
- W2066682485 cites W2018540975 @default.
- W2066682485 cites W2027397755 @default.
- W2066682485 cites W2032149167 @default.
- W2066682485 cites W2035780054 @default.
- W2066682485 cites W2041130203 @default.
- W2066682485 cites W2051605073 @default.
- W2066682485 cites W2055354000 @default.
- W2066682485 cites W2070862775 @default.
- W2066682485 cites W2077274919 @default.
- W2066682485 cites W2078917772 @default.
- W2066682485 cites W2095432377 @default.
- W2066682485 cites W2110572140 @default.
- W2066682485 cites W2117354924 @default.
- W2066682485 cites W2118519973 @default.
- W2066682485 cites W2143542298 @default.
- W2066682485 cites W2167911065 @default.
- W2066682485 cites W249991690 @default.
- W2066682485 cites W3023211482 @default.
- W2066682485 doi "https://doi.org/10.1016/0006-2952(92)90050-s" @default.
- W2066682485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1632830" @default.
- W2066682485 hasPublicationYear "1992" @default.
- W2066682485 type Work @default.
- W2066682485 sameAs 2066682485 @default.
- W2066682485 citedByCount "20" @default.
- W2066682485 countsByYear W20666824852013 @default.
- W2066682485 countsByYear W20666824852014 @default.
- W2066682485 countsByYear W20666824852015 @default.
- W2066682485 countsByYear W20666824852022 @default.
- W2066682485 crossrefType "journal-article" @default.
- W2066682485 hasAuthorship W2066682485A5027668355 @default.
- W2066682485 hasAuthorship W2066682485A5069829098 @default.
- W2066682485 hasConcept C126322002 @default.
- W2066682485 hasConcept C134018914 @default.
- W2066682485 hasConcept C150903083 @default.
- W2066682485 hasConcept C160160445 @default.
- W2066682485 hasConcept C178790620 @default.
- W2066682485 hasConcept C181199279 @default.
- W2066682485 hasConcept C185592680 @default.
- W2066682485 hasConcept C20251656 @default.
- W2066682485 hasConcept C207001950 @default.
- W2066682485 hasConcept C2777318727 @default.
- W2066682485 hasConcept C2779679107 @default.
- W2066682485 hasConcept C538909803 @default.
- W2066682485 hasConcept C540031477 @default.
- W2066682485 hasConcept C55493867 @default.
- W2066682485 hasConcept C62231903 @default.
- W2066682485 hasConcept C71924100 @default.
- W2066682485 hasConcept C86803240 @default.
- W2066682485 hasConcept C98274493 @default.
- W2066682485 hasConceptScore W2066682485C126322002 @default.
- W2066682485 hasConceptScore W2066682485C134018914 @default.
- W2066682485 hasConceptScore W2066682485C150903083 @default.
- W2066682485 hasConceptScore W2066682485C160160445 @default.
- W2066682485 hasConceptScore W2066682485C178790620 @default.
- W2066682485 hasConceptScore W2066682485C181199279 @default.
- W2066682485 hasConceptScore W2066682485C185592680 @default.
- W2066682485 hasConceptScore W2066682485C20251656 @default.
- W2066682485 hasConceptScore W2066682485C207001950 @default.
- W2066682485 hasConceptScore W2066682485C2777318727 @default.
- W2066682485 hasConceptScore W2066682485C2779679107 @default.
- W2066682485 hasConceptScore W2066682485C538909803 @default.
- W2066682485 hasConceptScore W2066682485C540031477 @default.
- W2066682485 hasConceptScore W2066682485C55493867 @default.
- W2066682485 hasConceptScore W2066682485C62231903 @default.
- W2066682485 hasConceptScore W2066682485C71924100 @default.
- W2066682485 hasConceptScore W2066682485C86803240 @default.
- W2066682485 hasConceptScore W2066682485C98274493 @default.
- W2066682485 hasIssue "1" @default.
- W2066682485 hasLocation W20666824851 @default.
- W2066682485 hasLocation W20666824852 @default.
- W2066682485 hasOpenAccess W2066682485 @default.
- W2066682485 hasPrimaryLocation W20666824851 @default.
- W2066682485 hasRelatedWork W1974921848 @default.
- W2066682485 hasRelatedWork W1998649742 @default.
- W2066682485 hasRelatedWork W2177783539 @default.
- W2066682485 hasRelatedWork W2336266117 @default.
- W2066682485 hasRelatedWork W2412132996 @default.
- W2066682485 hasRelatedWork W2774983008 @default.
- W2066682485 hasRelatedWork W3201683338 @default.
- W2066682485 hasRelatedWork W599209205 @default.
- W2066682485 hasRelatedWork W2183841546 @default.
- W2066682485 hasRelatedWork W2184880403 @default.
- W2066682485 hasVolume "44" @default.
- W2066682485 isParatext "false" @default.
- W2066682485 isRetracted "false" @default.